Wang Ziyi, Ding Meng, Lin Zhe, He Cuiwei, Zhao Yuqing
School of Pharmacy, Guangxi University of Traditional Chinese Medicine, Nanning, 530020, P. R. China.
School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang, 110016, P. R. China.
Chem Biodivers. 2019 Aug;16(8):e1900188. doi: 10.1002/cbdv.201900188. Epub 2019 Jul 12.
Panaxadiol is a dammarane-type ginsenoside having high ginseng content. The 3-hydroxy group of panaxadiol (PD) was modified by fatty acids and diacids. The modified panax glycol had enhanced anticancer activity. Twelve PD derivatives were evaluated and purified by chemical synthesis, column chromatography, co-synthesis, and identification. The human leukemia cells THP-1, HL-60, and human prostate cancer cell lines PC-3 were evaluated; PD derivatives were tested and evaluated in vitro by MTT assay. The results showed that the antitumor activities of some derivatives on three tumor cell lines were better than those of PD.
人参二醇是一种人参含量高的达玛烷型人参皂苷。人参二醇（PD）的3-羟基被脂肪酸和二酸修饰。修饰后的人参二醇具有增强的抗癌活性。通过化学合成、柱色谱、共合成和鉴定对12种PD衍生物进行了评估和纯化。对人白血病细胞THP-1、HL-60和人前列腺癌细胞系PC-3进行了评估；通过MTT法在体外对PD衍生物进行了测试和评估。结果表明，一些衍生物对三种肿瘤细胞系的抗肿瘤活性优于PD。
