Dana Seyyed Mohammad Matin Alavi, Meghdadi Mohammadreza, Kakhki Saeed Khayat, Khademi Reza
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Hematology and Blood Banking, Faculty of Medical Science, Mashhad University of Medical Science, Mashhad, Iran.
Curr Ther Res Clin Exp. 2024 Feb 25;100:100739. doi: 10.1016/j.curtheres.2024.100739. eCollection 2024.
Leukemia is a prevalent disease with high mortality and morbidity rates. Current therapeutic approaches are expensive and have side effects.
In this investigation, we reviewed studies that investigated the anticancer effects of ginsenoside derivatives against leukemia and also explained the three main Ginsenoside derivatives (ginsenoside Rg3, Rh2, and Rg1) separately.
An extensive search was conducted in Pubmed, Web of Science, and Google Scholar and relevant studies that investigated anticancer effects of ginsenoside derivatives against leukemia cancer were extracted and reviewed.
Preclinical studies reported that ginsenoside derivatives can induce apoptosis, suppress the proliferation of cancer cells, and induce differentiation and cell cycle arrest in leukemia cells. in addition, it can suppress the chemokine activity and extramedullary infiltration of leukemia cells from bone marrow. using herbal medicine and its derivatives is a promising approach to current health problems.
This review shows that ginsenoside derivatives can potentially suppress the growth of leukemia cells via various pathways and can be applied as a new natural medicine for future clinical research.
白血病是一种发病率和死亡率都很高的常见疾病。目前的治疗方法昂贵且有副作用。
在本研究中，我们回顾了研究人参皂苷衍生物抗白血病抗癌作用的研究，并分别解释了三种主要的人参皂苷衍生物（人参皂苷Rg3、Rh2和Rg1）。
在PubMed、科学网和谷歌学术上进行了广泛搜索，提取并回顾了研究人参皂苷衍生物抗白血病抗癌作用的相关研究。
临床前研究报告称，人参皂苷衍生物可诱导白血病细胞凋亡、抑制癌细胞增殖、诱导分化和细胞周期停滞。此外，它还可以抑制趋化因子活性和白血病细胞从骨髓的髓外浸润。使用草药及其衍生物是解决当前健康问题的一种有前途的方法。
本综述表明，人参皂苷衍生物可通过多种途径潜在地抑制白血病细胞生长，并可作为一种新的天然药物用于未来的临床研究。
