Department of Neuroscience, Mortimer B. Zuckerman Institute for Mind Brain Behavior, Kavli Institute for Brain Sciences, Columbia University, New York, NY, United States.
Department of Neuroscience, Mortimer B. Zuckerman Institute for Mind Brain Behavior, Kavli Institute for Brain Sciences, Columbia University, New York, NY, United States.
Curr Opin Neurobiol. 2019 Dec;59:146-156. doi: 10.1016/j.conb.2019.05.006. Epub 2019 Jul 9.
One of the hallmarks of the metazoan genome is that genes are non-randomly positioned within the cell nucleus; in fact, the entire genome is packaged in a highly organized manner to orchestrate proper gene expression for each cell type. This is an especially daunting task for the development of the brain, which consists of an incredibly diverse population of neural cells. How genome architecture is established, maintained, and regulated to promote diverse cell fates and functions are fascinating questions with important implications in development and disease. The explosion in various biochemical and imaging techniques to analyze chromatin is now making it possible to interrogate the genome at an unprecedented resolution. Here we will focus on current advances in understanding genome architecture and gene regulation in the context of neural development.
后生动物基因组的一个显著特征是基因在细胞核内是非随机排列的；事实上，整个基因组以高度组织化的方式进行包装，以协调每种细胞类型的适当基因表达。对于由大量不同类型的神经细胞组成的大脑发育来说，这是一项特别艰巨的任务。基因组结构如何建立、维持和调节，以促进不同的细胞命运和功能，是一个令人着迷的问题，对发育和疾病具有重要意义。现在，各种分析染色质的生化和成像技术的爆炸式发展，使得以前所未有的分辨率来探究基因组成为可能。在这里，我们将重点介绍在神经发育背景下理解基因组结构和基因调控的最新进展。
