Colin E, Baldolli A, Verdon R, Saint-Lorant G
Pharmacie centrale, CHU de Caen, avenue de la Côte-de-Nacre, 14000 Caen, France.
Service de maladies infectieuses et tropicales, CHU de Caen, avenue de la Côte-de-Nacre, 14000 Caen, France.
Med Mal Infect. 2020 May;50(3):231-242. doi: 10.1016/j.medmal.2019.06.007. Epub 2019 Jul 9.
The subcutaneous route is a widely used route of administration in routine clinical practice, particularly in elderly patients, when the intravenous route cannot be used. This review of the literature highlights the lack of randomized studies and the lack of pharmacokinetic data on the use of this route of administration. Three antibiotics administered subcutaneously can be used for severe infections, with acceptable pharmacokinetic and pharmacodynamic data, when the intravenous administration is not possible: ceftriaxone, ertapenem, and teicoplanin.
皮下途径是常规临床实践中广泛使用的给药途径，尤其是在无法采用静脉途径给药时的老年患者中。这篇文献综述强调了关于该给药途径使用的随机研究的缺乏以及药代动力学数据的不足。当无法进行静脉给药时，三种皮下给药的抗生素可用于严重感染，其药代动力学和药效学数据是可接受的，这三种抗生素为头孢曲松、厄他培南和替考拉宁。
