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病毒性结膜炎:澳大利亚一家医院的回顾性研究。

Viral conjunctivitis: a retrospective study in an Australian hospital.

机构信息

The University of Sydney, Sydney, New South Wales, Australia.

The University of Sydney, Save Sight Institute, Discipline of Ophthalmology, Sydney Medical School, Sydney, New South Wales, Australia.

出版信息

Cont Lens Anterior Eye. 2019 Dec;42(6):679-684. doi: 10.1016/j.clae.2019.07.001. Epub 2019 Jul 9.

DOI:10.1016/j.clae.2019.07.001
PMID:31300283
Abstract

IMPORTANCE

To update the literature on the current trends of viral conjunctivitis infections in Sydney, Australia.

BACKGROUND

To find correlations between viral and patient characteristics on disease outcomes and to assess the rates of antibiotic and steroid use in patients with viral conjunctivitis prior to and after assessment by ophthalmology trainees.

DESIGN

Retrospective single-centre case series.

PARTICIPANTS

368 eyes of 224 patients diagnosed with viral conjunctivitis at the Sydney Eye Hospital from 1 st January - 31 st March 2017.

METHODS

Patients were identified from hospital records or polymerase chain reaction results.

RESULTS

368 eyes of 224 patients, median age 35.3 (range 7-82) and 59.8% males, were included. 152 (67.9%) patients presented already on antibiotic treatment. Most patients (83.5%) had no previous ocular history aside from 35 (15.6%) who were regular contact lens wearers. PCR was performed in 170 (75.9%) patients, with 92 (54.1%) positive for adenovirus, and 7 (4.1%) for HSV. The average duration of symptoms prior to presentation was 6.3 days. 177 (78.0%) patients presented within 1 week of symptom onset and these patients were more likely to be adenovirus positive on PCR (OR = 2.37). Patients with symptoms of longer duration were more likely to have photophobia (OR = 2.96) and have had steroid treatment (OR = 3.80).

CONCLUSIONS AND RELEVANCE

Patients with viral conjunctivitis typically presented within a week of symptom onset, with bilateral disease and on topical antibiotics. Pseudomembranes and a palpable preauricular lymph node were not common. As treatments emerge for viral conjunctivitis patients may need to be encouraged to present earlier.

摘要

目的

更新澳大利亚悉尼病毒性结膜炎感染的当前趋势文献。

背景

为了找到病毒和患者特征之间的相关性,以及评估在眼科受训者评估之前和之后,患有病毒性结膜炎的患者使用抗生素和类固醇的比率。

设计

回顾性单中心病例系列。

参与者

2017 年 1 月 1 日至 3 月 31 日在悉尼眼科医院诊断为病毒性结膜炎的 224 名患者的 368 只眼。

方法

通过医院记录或聚合酶链反应结果识别患者。

结果

纳入了 224 名患者的 368 只眼,中位年龄 35.3(范围 7-82),男性占 59.8%。152(67.9%)名患者已经接受了抗生素治疗。除了 35 名(15.6%)常规隐形眼镜佩戴者外,大多数患者(83.5%)除结膜炎外无其他眼部病史。170(75.9%)名患者进行了 PCR,92(54.1%)为腺病毒阳性,7(4.1%)为 HSV。就诊前症状的平均持续时间为 6.3 天。177(78.0%)名患者在症状发作后 1 周内就诊,这些患者在 PCR 上更有可能为腺病毒阳性(OR=2.37)。症状持续时间较长的患者更有可能出现畏光(OR=2.96)和接受过类固醇治疗(OR=3.80)。

结论和相关性

病毒性结膜炎患者通常在症状发作后一周内就诊,双眼发病,伴有局部抗生素治疗。假膜和可触及的耳前淋巴结并不常见。随着针对病毒性结膜炎患者的治疗方法的出现,可能需要鼓励患者更早就诊。

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