Department of Ophthalmology, Balıkesir University Medicine Faculty, 10045, Balıkesir, Turkey.
Department of Ophthalmology, Ege University Medicine Faculty, Izmir, Turkey.
Int Ophthalmol. 2022 May;42(5):1419-1425. doi: 10.1007/s10792-021-02130-3. Epub 2021 Nov 29.
Purpose To evaluate the ocular surface properties in epidemic keratoconjunctivitis (EKC) patients during healing process, and to detect the damage on conjunctival goblet cells. Methods Bilateral EKC patients confirmed with polymerase chain reaction (PCR) testing were included. Firstly (Group 1) and secondly (Group 2) affected eyes were compared. Ocular surface parameters were performed at the first visit and first month. Results The study included 34 eyes of 17 patients. The mean age was 44.54 ± 16.80 (21-70) years (FM/M 20/14). The ocular findings in Groups 1 and 2 were not significant. For Groups 1 and 2, OSDI was 53.53 ± 23.01 and 35.90 ± 22.19 (p 0.03), tear osmolarity was 309.12 ± 19.38 and 297.47 ± 8.27 mOsm/µL (p 0.029), OSSS was 1.00 ± 0.79 and 0.18 ± 0.39 (p 0.001), T-BUT was 3.59 ± 2.29 and 6.00 ± 1.83 s (p 0.002), and Schirmer's 1 test was 10.94 ± 8.42 and 16.76 ± 9.05 mm (p 0.061), respectively. In Groups 1 and 2, the IC was Grade (G) 0 in 23.5% and 17.6%, G1 in 35.3% and 41.2%, and G2 in 41.2% and 41.2%, respectively. The ocular surface properties were worse in Group 1 than Group 2, and the difference was significant except for Schirmer's 1 test and IC. Conclusions Dry eye disorder is a complication of EKC and may cause a significant decrease in quality of life.
目的 评估流行性角膜结膜炎（EKC）患者在愈合过程中的眼表特性，并检测结膜杯状细胞的损伤。
方法 纳入经聚合酶链反应（PCR）检测确诊的双侧 EKC 患者。首先（第 1 组）和其次（第 2 组）受累眼进行比较。在首次就诊和第 1 个月进行眼表参数检查。
结果 研究纳入 17 例患者的 34 只眼。平均年龄为 44.54±16.80 岁（21-70 岁）（FM/M 20/14）。第 1 组和第 2 组的眼部表现无显著差异。第 1 组和第 2 组的 OSDI 分别为 53.53±23.01 和 35.90±22.19（p 0.03），泪液渗透压分别为 309.12±19.38 和 297.47±8.27 mOsm/µL（p 0.029），OSSS 分别为 1.00±0.79 和 0.18±0.39（p 0.001），T-BUT 分别为 3.59±2.29 和 6.00±1.83 s（p 0.002），Schirmer 测试值分别为 10.94±8.42 和 16.76±9.05 mm（p 0.061）。第 1 组和第 2 组中，IC 分级（G）0 级分别为 23.5%和 17.6%，G1 级分别为 35.3%和 41.2%，G2 级分别为 41.2%和 41.2%。第 1 组的眼表特征比第 2 组差，除 Schirmer 测试和 IC 外，其余差异均有统计学意义。
结论 干眼症是 EKC 的并发症，可能导致生活质量显著下降。
