Ozawa T, Nishikimi M, Sugiyama S, Taki F, Hayakawa M, Shionoya H
Department of Biomedical Chemistry, Faculty of Medicine, University of Nagoya, Japan.
Biochem Int. 1988 Feb;16(2):369-73.
Leukotoxin (LX: 9,10-epoxy-12-octadecenoate) which was previously found to be biosynthesized by neutrophils, exhibited a dominant cytotoxic activity toward human tumor cells as well as toward normal cells. At the concentration of 50-100 micrograms LX/ml cell culture medium, LX completely blocked the growth of the cells of several transformed cell lines (HeLa, Hep-2, MG-63, Chang liver, Wish, FL-Amnion) as well as the normal (Flow 2000 and Flow 13000). From the results, a part of inhibition of tumor growth by neutrophils can be attributed to LX.
白细胞毒素（LX：9,10-环氧-12-十八碳烯酸酯）先前被发现由中性粒细胞生物合成，对人类肿瘤细胞以及正常细胞均表现出显著的细胞毒性活性。在细胞培养基中LX浓度为50 - 100微克/毫升时，LX完全抑制了几种转化细胞系（HeLa、Hep-2、MG-63、张氏肝细胞、Wish、FL-羊膜细胞）以及正常细胞（Flow 2000和Flow 13000）的生长。从这些结果来看，中性粒细胞对肿瘤生长的部分抑制作用可归因于LX。
