Inserm U1153-CRESS HERA Team, Faculté de Pharmacie de Paris, Université Paris Descartes, France.
ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; CIBER Epidemiologia y Salud Publica (CIBERESP), Spain.
Environ Int. 2019 Oct;131:104984. doi: 10.1016/j.envint.2019.104984. Epub 2019 Jul 10.
Few studies have investigated the 24-hour respiratory health effects of personal black carbon (BC) and ultrafine particles (UFP) exposure in schoolchildren. The objective of this study was to investigate these associations with the lung function in children 10-years old with and without persistent respiratory symptoms.
We conducted a cross-sectional study in 305 children (147 and 158 with and without persistent respiratory symptoms, respectively) from three European birth-cohorts: PARIS (France) and INMA Sabadell and Valencia (Spain). Personal 24-hour measurements of exposure concentrations to BC and UFP were performed by portable devices, before lung function testing. Forced expiratory volume in 1 s (FEV), forced vital capacity (FVC) and the fraction of exhaled nitric oxide (FeNO) were determined.
There was no association of UFP with lung function parameters or FeNO whereas the increase in 24-hour BC exposure concentrations was related to a statistically significant decrease in lung function parameters only among children with persistent respiratory symptoms [-96.8 mL (95% Confidence Interval CI: -184.4 to -9.1 mL) in FVC, and -107.2 mL (95% CI: -177.5 to -36.9 mL) in FEV for an inter-quartile range of 1160 ng/m exposure increase]. A significant positive association between BC and FeNO was observed only in children with persistent respiratory symptoms with current wheezing and/or medication to improve breathing [FeNO increases with +6.9 ppb (95% CI: 0.7 to 13.1 ppb) with an inter-quartile range BC exposure increase].
Children suffering from persistent respiratory symptoms appear to be more vulnerable to BC exposure.
很少有研究调查儿童个人黑碳（BC）和超细颗粒（UFP）暴露 24 小时对呼吸健康的影响。本研究的目的是调查这些与 10 岁儿童肺功能的关联，这些儿童患有持续性呼吸道症状和不患有持续性呼吸道症状。
我们在来自三个欧洲出生队列的 305 名儿童（分别为 147 名和 158 名患有持续性呼吸道症状和不患有持续性呼吸道症状的儿童）中进行了一项横断面研究：PARIS（法国）和 INMA 萨瓦德尔和巴伦西亚（西班牙）。通过便携式设备在肺功能测试前进行个人 24 小时暴露浓度测量。用力呼气量（FEV）、用力肺活量（FVC）和呼出的一氧化氮分数（FeNO）均被测定。
UFP 与肺功能参数或 FeNO 均无关联，而 24 小时 BC 暴露浓度的增加仅与持续性呼吸道症状儿童的肺功能参数显著降低有关[-FVC 中 96.8 mL（95%置信区间 CI：-184.4 至 -9.1 mL），FEV 中 -107.2 mL（95% CI：-177.5 至 -36.9 mL），BC 暴露增加 1160ng/m 的四分位间距]。仅在患有持续性呼吸道症状且目前有喘息和/或改善呼吸的药物治疗的儿童中观察到 BC 和 FeNO 之间存在显著的正相关[FeNO 随 BC 暴露增加而增加+6.9 ppb（95% CI：0.7 至 13.1 ppb）]。
患有持续性呼吸道症状的儿童似乎更容易受到 BC 暴露的影响。
