环状 RNA 在β细胞功能和 2 型糖尿病相关并发症中的作用：一种潜在的诊断和治疗方法。
Circular RNAs in β-cell function and type 2 diabetes-related complications: a potential diagnostic and therapeutic approach.
机构信息
Department of Clinical Biochemistry, Abadan Faculty of Medical Sciences, Abadan, Iran.
Student Research Committee, Abadan Faculty of Medical Sciences, Abadan, Iran.
出版信息
Mol Biol Rep. 2019 Oct;46(5):5631-5643. doi: 10.1007/s11033-019-04937-x. Epub 2019 Jul 13.
Recent investigations have indicated that altered expression of non-coding RNAs (ncRNAs) could be associated with human diseases such as type 2 diabetes (T2D). Circular RNAs (circRNAs) are a new discovered class of ncRNAs with unique structural characteristics that involved in several molecular and cellular functions. Exploring of the circulating circRNAs as a reliable non-invasive biomarker for monitoring and diagnosing of human diseases has grown significantly. However, the molecular functions and clinical relevance of circRNAs are not yet well clarified in T2D. Accordingly, in this review, the involvement of circRNAs in the β-cell function and T2D-related complications is highlighted. The study also shed light on the possibility of using circRNAs as a biomarker for T2D diagnosis.
最近的研究表明，非编码 RNA（ncRNA）表达的改变可能与人类疾病有关，如 2 型糖尿病（T2D）。circRNAs 是一类新发现的 ncRNA，具有独特的结构特征，参与多种分子和细胞功能。作为监测和诊断人类疾病的可靠非侵入性生物标志物，循环 circRNAs 的研究显著增加。然而，circRNAs 在 T2D 中的分子功能和临床相关性尚不清楚。因此，在本综述中，重点阐述了 circRNAs 在β细胞功能和 T2D 相关并发症中的作用。该研究还探讨了 circRNAs 作为 T2D 诊断生物标志物的可能性。
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