Wada Jun
Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita-ku, Okayama, Japan.
J Diabetes Investig. 2025 Jan;16(1):8-9. doi: 10.1111/jdi.14331. Epub 2024 Oct 3.
In both human clinical and animal experimental studies, the altered expression of regulatory RNAs such as miRNAs, lncRNAs, and circRNAs are reported in diabetes and its complications by investigating various samples of serum, plasma, whole blood, and tissues. These identified ncRNAs are candidates for the disease diagnostic markers, prognostic markers, and also therapeutic targets. In the updates, the recently published ncRNAs involved in the onset and progression of DKD are discussed.
在人体临床研究和动物实验研究中，通过对血清、血浆、全血和组织等各种样本进行研究，发现糖尿病及其并发症中存在miRNA、lncRNA和circRNA等调控RNA的表达改变。这些已鉴定出的非编码RNA是疾病诊断标志物、预后标志物以及治疗靶点的候选者。在本综述中，将讨论最近发表的与糖尿病肾病发生和发展相关的非编码RNA。
