Ramezankhani Azra, Harati Hadi, Bozorgmanesh Mohammadreza, Tohidi Maryam, Khalili Davood, Azizi Fereidoun, Hadaegh Farzad
Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Biostatistics and Epidemiology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Int J Endocrinol Metab. 2018 Oct 16;16(4 Suppl):e84784. doi: 10.5812/ijem.84784. eCollection 2018 Oct.
We summarized findings from Tehran lipid and glucose study (TLGS) about different aspects of type 2 diabetes (T2D) over the span of nearly 2 decades.
A review was undertaken to retrieve papers related to all aspects of T2D from the earliest date available up to January 30, 2018.
An annual crude incidence rate of 10 per 1000 person-years of follow-up was found for T2D in adult participants. Overall incidence rate of pre-diabetes/T2D was 36.3 per 1000 person-years or about 1% each year among youth. Diabetes was associated with increased risk of CVD [hazard ratio (HR): 1.86, 95% confidence interval (95% CI): 1.57 - 2.27] and mortality [HR: 2.56; 95% CI: 2.08 - 3.16] in the total population. Compared with non-diabetic men and women, their diabetic counterparts survived 1.4 and 0.7 years shorter, respectively, during 15 years of follow-up. Wrist circumference, hyperinsulinaemia, 25-hydroxy vitamin D and increase in alanin aminotranferase provided incremental prognostic information beyond the traditional risk factors for incident T2D in adults. Using decision tree algorithms, a number of high risk groups were found for incident T2D. A probability of 84% was found for incidence of T2D among a group of men with fasting plasma glucose (FPG) > 5.3 mmol/L and waist to height ratio (WHtR) > 0.56, and women with FPG > 5.2 mmol/L and WHtR > 0.56.
Original TLGS studies have contributed greatly to clarify important evidence regarding the epidemiology and risk factors for T2D among Iranian population.
我们总结了德黑兰血脂与血糖研究（TLGS）在近20年期间关于2型糖尿病（T2D）不同方面的研究结果。
进行了一项综述，以检索从可获得的最早日期到2018年1月30日与T2D各方面相关的论文。
在成年参与者中，T2D的年粗发病率为每1000人年随访10例。糖尿病前期/T2D的总体发病率为每1000人年36.3例，在年轻人中每年约为1%。在总人口中，糖尿病与心血管疾病风险增加相关[风险比（HR）：1.86，95%置信区间（95%CI）：1.57 - 2.27]和死亡率增加相关[HR：2.56；95%CI：2.08 - 3.16]。与非糖尿病男性和女性相比，他们的糖尿病对应者在15年的随访期间分别少活1.4年和0.7年。腕围、高胰岛素血症、25-羟基维生素D和丙氨酸转氨酶升高提供了超越成人新发T2D传统危险因素的增量预后信息。使用决策树算法，发现了一些新发T2D的高危人群。在一组空腹血糖（FPG）>5.3 mmol/L且腰高比（WHtR）>0.56的男性以及FPG>5.2 mmol/L且WHtR>0.56的女性中，T2D发病的概率为84%。
最初的TLGS研究在阐明伊朗人群中T2D的流行病学和危险因素的重要证据方面做出了巨大贡献。
