Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA.
Int J Cancer. 2020 May 1;146(9):2442-2449. doi: 10.1002/ijc.32574. Epub 2019 Jul 26.
Tea and coffee have antioxidant and neuroprotective effects. Observational studies suggest that tea and coffee intake may reduce cancer risk, but data on glioma risk are inconclusive. We evaluated the association between tea, coffee and caffeine intake and glioma risk in the female Nurses' Health Study (NHS) and Nurses' Health Study II (NHSII) and the male Health Professionals Follow-Up Study (HPFS). Cumulative intake was derived from validated quadrennial food frequency questionnaires. Glioma cases were confirmed by medical record review. Multivariable-adjusted hazard ratios of glioma by beverage intake category were estimated using Cox proportional hazards models. We documented 554 incident cases of glioma (256 in NHS, 87 in NHSII and 211 in HPFS). Compared to <1 cup/week, higher tea consumption was borderline inversely associated with glioma risk in pooled cohorts (hazard ratio [HR] = 0.73, 95% confidence interval [CI]: 0.49-1.10 for >2 cups/day, p-trend = 0.05), but not in women (HR = 0.74, 95% CI: 0.47-1.18 for >2 cups/day, p-trend = 0.11) or men (HR = 0.70, 95% CI: 0.30-1.60 for >2 cups/day, p-trend = 0.30) separately. Overall, we observed no significant associations between caffeinated, decaffeinated or total coffee intake and glioma risk. There were no material differences in the results with baseline values, 8-year lagged responses, or when limited to glioblastoma (n = 362). In three large prospective cohort studies, tea intake was borderline inversely associated with glioma risk. No significant associations were observed for coffee intake and glioma risk. These results merit further exploration in prospective studies.
茶和咖啡具有抗氧化和神经保护作用。观察性研究表明，饮茶和喝咖啡可能降低癌症风险，但关于胶质瘤风险的数据尚无定论。我们评估了女性护士健康研究（NHS）和护士健康研究 II（NHSII）以及男性健康专业人员随访研究（HPFS）中茶、咖啡和咖啡因摄入量与胶质瘤风险之间的关联。累积摄入量来自经过验证的四年一次的食物频率问卷。通过病历审查确认胶质瘤病例。使用 Cox 比例风险模型估计按饮料摄入量类别分类的胶质瘤风险的多变量调整后的危险比。我们记录了 554 例胶质瘤病例（NHS 中有 256 例，NHSII 中有 87 例，HPFS 中有 211 例）。与每周<1 杯相比，在汇总队列中，较高的茶消费量与胶质瘤风险呈临界负相关（风险比[HR]为 0.73，95%置信区间[CI]为 0.49-1.10，趋势检验 P=0.05），但在女性（HR=0.74，95%CI：0.47-1.18，趋势检验 P=0.11）或男性（HR=0.70，95%CI：0.30-1.60，趋势检验 P=0.30）中无显著关联。总的来说，我们观察到含咖啡因、脱咖啡因或总咖啡摄入量与胶质瘤风险之间没有显著关联。在基线值、8 年滞后反应或仅限于胶质母细胞瘤（n=362）时，结果没有明显差异。在三项大型前瞻性队列研究中，茶的摄入量与胶质瘤风险呈临界负相关。咖啡摄入量与胶质瘤风险之间没有显著关联。这些结果值得在前瞻性研究中进一步探讨。
