Acute pulmonary thromboembolism caused by factor V Leiden mutation in South Korea: A case report.

RATIONALE

Although Factor V Leiden (FVL) mutation is a major cause of inherited thrombophilia in Western populations; the mutation is extremely rare in Asia.

PATIENT CONCERNS

Here we report a case of a 28-year old Korean woman admitted to our hospital with extensive pulmonary embolism.

DIAGNOSIS

She was heterozygous for FVL mutation up on evaluation, and screening for asymptomatic family members also revealed heterozygous FVL mutation for her mother.

INTERVENTIONS

Enoxaparin 1 mg/kg was initiated, followed by rivaroxaban 15 mg every 12 hours.

OUTCOMES

The patient showed improvement in both subjective dyspnea and right ventricular dysfunction and was successfully discharged after five hospital days.

LESSONS

FVL mutation screening may be considered in Asian patients with thrombophilia of uncertain etiology in the future.