University of Pennsylvania and the Fox Chase Cancer Center, Philadelphia, Pennsylvania; and the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Obstet Gynecol. 2019 Aug;134(2):376-384. doi: 10.1097/AOG.0000000000003379.
To estimate whether targeted educational interventions can increase human papillomavirus (HPV) vaccine acceptability and knowledge among young women.
An exploratory phase of the study was conducted to determine baseline acceptance of the prophylactic HPV vaccine and barriers to acceptance. Based on the results of that phase of the study, a randomized controlled trial of women aged 12-26 at a single institution was completed. A sample size of at least 84 women in each of three study arms (control, educational handout, or educational video) was planned to detect a 20% difference in vaccine acceptability among arms. All participants completed a survey collecting data on demographics, HPV vaccine preferences, and HPV vaccine knowledge after completion of their randomization assignments. The primary outcome was HPV vaccine acceptability. The secondary outcome was HPV vaccine knowledge.
From March 2017 through August 2017, 256 women were randomized to one of three study arms: control (n=85), educational handout (n=84), or educational video (n=87). Demographics were similar between study arms. Overall, 51.7% of participants in the educational video arm reported willingness to accept the HPV vaccine compared with 33.3% and 28.2% of participants in the educational handout and control arms, respectively (P<.01). Those in the educational video and handout arms had higher median HPV vaccine knowledge scores than those in the control arm (6 and 5 vs 3, P<.01). Both interventions were reported as helpful in learning (97.7% vs 92.9%, P=.15), but the educational video arm was more likely to be helpful in deciding on vaccination (86.2% vs 70.2%, P<.01).
Targeted educational interventions increase HPV vaccine acceptability and knowledge among young women. Follow up studies are needed to determine whether these interventions also increase rates of vaccine uptake and series completion.
Clinicaltrials.gov, NCT03337269.
评估有针对性的教育干预措施是否可以提高年轻女性对人乳头瘤病毒（HPV）疫苗的接受度和认知。
本研究进行了探索性阶段，以确定预防性 HPV 疫苗的基线接受程度和接受障碍。基于该阶段的研究结果，在一家机构完成了一项针对 12-26 岁女性的随机对照试验。计划在三个研究组（对照组、教育手册组或教育视频组）中的每个组中至少有 84 名女性，以检测组间疫苗接受率差异 20%。所有参与者在完成随机分组后完成一项调查，收集人口统计学、HPV 疫苗偏好和 HPV 疫苗知识数据。主要结局是 HPV 疫苗接受度。次要结局是 HPV 疫苗知识。
2017 年 3 月至 2017 年 8 月，共有 256 名女性被随机分配到三个研究组之一：对照组（n=85）、教育手册组（n=84）或教育视频组（n=87）。研究组间的人口统计学特征相似。总体而言，教育视频组中 51.7%的参与者表示愿意接受 HPV 疫苗，而教育手册组和对照组分别为 33.3%和 28.2%（P<.01）。教育视频组和教育手册组的 HPV 疫苗知识中位数得分均高于对照组（6 分和 5 分比 3 分，P<.01）。两组干预措施均被报告为有助于学习（97.7%比 92.9%，P=.15），但教育视频组在决定接种疫苗方面更有帮助（86.2%比 70.2%，P<.01）。
有针对性的教育干预措施提高了年轻女性对 HPV 疫苗的接受度和认知。需要进一步的研究来确定这些干预措施是否也能提高疫苗接种率和系列完成率。
Clinicaltrials.gov，NCT03337269。
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