猪痢疾蛇形螺旋体（A）基因使大肠杆菌对截短侧耳素类和链阳性菌素 A 的敏感性降低。
The (A) Gene from Brachyspira hyodysenteriae Confers Decreased Susceptibility to Pleuromutilins and Streptogramin A in Escherichia coli.
机构信息
Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
出版信息
Antimicrob Agents Chemother. 2019 Aug 23;63(9). doi: 10.1128/AAC.00930-19. Print 2019 Sep.
Abstract
The (A) gene suspected to confer resistance to pleuromutilins in was tested for functionality in AG100A and RN4220. Expression of the cloned (A) gene conferred decreased susceptibility to pleuromutilin (P) and streptogramin A (S) antibiotics in and had a minor effect in The finding provides evidence of the direct association of (A) with the PS resistance phenotype.
摘要
被怀疑可赋予 对截短侧耳素类药物耐药性的 (A) 基因，在 AG100A 和 RN4220 中进行了功能测试。克隆的 (A) 基因的表达使 和 对截短侧耳素类药物（P）和链阳性菌素 A（S）抗生素的敏感性降低，并且对 的影响较小。这一发现提供了 (A) 与 PS 耐药表型直接关联的证据。
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