Al Hayek Ayman A, Robert Asirvatham A, Al Dawish Mohamed A
Department of Endocrinology and Diabetes, Diabetes Treatment Center, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
Clin Med Insights Endocrinol Diabetes. 2019 Jul 1;12:1179551419861102. doi: 10.1177/1179551419861102. eCollection 2019.
To evaluate the different experience of freestyle libre and finger pricks on clinical characteristics and glucose monitoring satisfaction (GMS) in patients with type 1 diabetes (T1D) using insulin pump (IP).
A prospective study was carried out on 47 (aged 17-21 years) T1D, who used conventional finger-pricking method for self-testing the glucose. The experiments were conducted between March 2018 and September 2018. For carrying out the study, the flash glucose monitoring (FGM) sensors were placed on each participant, at the baseline visit, by a trained diabetes educator. Furthermore, to determine the total number of scans conducted during the study period, the respective ambulatory glucose profiles were generated by computing the data collected from the sensors. In addition, a trained interviewer handed over the GMS questionnaire to each patient, at the baseline and at 12 weeks of the study.
In comparison to the baseline (finger pricks), various parameters such as: HbA1c ( = .042), hypoglycemia ( = .001), mean capillary glucose ( = .004), total daily insulin dose ( = .0001), percentage of bolus insulin ( = .0001), daily bolus frequency ( = .0001), and daily carbohydrates intake ( = .0001) showed a significant improvement at 12 weeks. Similarly, substantial augmentation was noticed, in the sub domains of GMS, that is, openness ( = .0001), emotional burden ( = .0001), behavioral burden ( = .0001), and trust ( = .0001) at 12 weeks as compared to baseline. Overall, total GMS score at baseline was 1.72 ± 0.37, which increased up to 3.41 ± 0.49 ( = .0001) in the time period of 12 weeks. The HbA1c (r = 0.45), hypoglycemia (r = 0.58), and the mean number of FGM scans, exhibited a negative correlation, while GMS (r = 0.52) and the mean number of FGM scans, exhibited a positive correlation.
The frequency of hypoglycemia, HbA1c level, capillary glucose, daily carbohydrates intake decreased, while the total daily insulin dose, daily bolus insulin and total GMS score increased with the use of FGM scanning for 12 weeks.
评估在使用胰岛素泵(IP)的1型糖尿病(T1D)患者中,使用自由式 Libre 与指尖采血在临床特征和血糖监测满意度(GMS)方面的不同体验。
对47名年龄在17 - 21岁的T1D患者进行了一项前瞻性研究,这些患者使用传统指尖采血法进行自我血糖检测。实验于2018年3月至2018年9月期间进行。为开展该研究,在基线访视时,由一名经过培训的糖尿病教育者在每位参与者身上放置闪光血糖监测(FGM)传感器。此外,通过计算从传感器收集的数据生成各自的动态血糖图谱,以确定研究期间进行的扫描总数。另外,在研究的基线和12周时,由一名经过培训的访谈者将GMS问卷交给每位患者。
与基线(指尖采血)相比,在12周时,诸如糖化血红蛋白(HbA1c,P = 0.042)、低血糖(P = 0.001)、平均毛细血管血糖(P = 0.004)、每日胰岛素总剂量(P = 0.0001)、大剂量胰岛素百分比(P = 0.0001)、每日大剂量胰岛素注射频率(P = 0.0001)以及每日碳水化合物摄入量(P = 0.0001)等各种参数均显示出显著改善。同样,与基线相比,在12周时GMS的子领域,即开放性(P = 0.0001)、情感负担(P = 0.0001)、行为负担(P = 0.0001)和信任(P = 0.0001)方面也有显著提高。总体而言,基线时GMS总分为1.72 ± 0.37,在12周期间增至高达3.41 ± 0.49(P = 0.0001)。糖化血红蛋白(r = 0.45)、低血糖(r = 0.58)与FGM扫描的平均次数呈负相关,而GMS(r = 0.52)与FGM扫描的平均次数呈正相关。
使用FGM扫描12周后,低血糖频率、糖化血红蛋白水平、毛细血管血糖、每日碳水化合物摄入量降低,而每日胰岛素总剂量、每日大剂量胰岛素和GMS总评分增加。