Goldhofer W, Kreienberg R, Kutzner J, Lemmel E M
Strahlentherapie. 1979 Apr;155(4):277-83.
Total irradiation of mice with 100 R, 350 R and 600 R leads to a significant decrease of T- and B-cells which depends directly on the irradiation dose. This decrease can already be demonstrated on the first day after the irradiation, it reaches its culminating point on the tenth day after the irradiation. After an irradiation with 100 R, the cells of the spleen or irradiated mice show no reduced capacity of being stimulated by phytohemagglutinine, Pokeweed mitogen, and concanavalin A, in case of an irradiation with 350 R this capacity is significantly reduced only until the third day after the irradiation. The animals irradiated with 600 R show a decrease on the first day, then they have a phase of recovery on the third day which is followed by a second decrease (biphasic depression). Independently of the irradiation energy, the reduced number of B- and T-cells in the irradiated mice returns to normal values until the 48th day of observation. The functional activities, however, show a disturbance the extension and duration of which are depending on the irradiation dose.
用100伦琴、350伦琴和600伦琴对小鼠进行全身照射会导致T细胞和B细胞显著减少，且这种减少直接取决于照射剂量。这种减少在照射后的第一天就已显现，在照射后的第十天达到顶点。用100伦琴照射后，脾脏细胞或受照射小鼠的细胞对植物血凝素、商陆有丝分裂原和刀豆球蛋白A的刺激能力未降低；用350伦琴照射时，这种能力仅在照射后的第三天之前显著降低。用600伦琴照射的动物在第一天出现减少，然后在第三天有一个恢复阶段，随后是第二次减少（双相抑制）。无论照射能量如何，受照射小鼠体内减少的B细胞和T细胞数量在观察的第48天之前恢复到正常值。然而，功能活性出现紊乱，其程度和持续时间取决于照射剂量。
