Hager Boris, Herzog Sereina A, Hager Barbara, Sandner-Kiesling Andreas, Zigeuner Richard, Pummer Karl
Department of Urology, Medical University of Graz, Graz, Austria.
Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.
Br J Pain. 2019 Aug;13(3):177-184. doi: 10.1177/2049463718808542. Epub 2018 Oct 23.
To explore whether the total pain experience differs after (partial) kidney tumour nephrectomies via flank, transabdominal or laparoscopic access.
We analyzed retrospectively 107 patients with flank, 12 with transabdominal and 21 with laparoscopic interventions. For pain treatment, conventional analgesics (A) or intravenous patient-controlled analgesia (PCIA) or thoracic peridural analgesia (tPDA) were used. Self-reported pain was measured with a Visual Analogue Scale three times daily. The area under the curve (AUC) at rest (R) and during a standardized body movement (M) were calculated from the intervention till the end of the second T(0-2) and seventh postoperative day T(0-7), respectively.
The median AUC for T(0-2) at R was more intense for laparoscopy (13) than for flank incision (A, 9) and approximately the same during M. For flank incisions (A), the median AUC at R rises from 9 for T(0-2) to 22 for T(0-7) and at M the median AUC increases from 18 to 37. In contrast, laparoscopy did not cause further pain after the second postoperative day. Furthermore, with flank incision for T(0-2), at R, tPDA was superior to A (median AUC: 5 versus 9, p = 0.02) and at M again tPDA (median AUC: 12) had a better pain-control as A (18) or even as PCIA (19, p = 0.005).
Laparoscopic nephrectomies cause a relatively intense mean cumulative pain for T(0-2) and a subsequent absence of pain. However, flank incisions went on to increased pain levels until the seventh postoperative day with tPDA as most effective therapy.
探讨经侧腹、经腹或腹腔镜途径行(部分)肾肿瘤肾切除术后总的疼痛体验是否存在差异。
我们回顾性分析了107例行侧腹手术、12例行经腹手术和21例行腹腔镜手术的患者。疼痛治疗采用传统镇痛药(A)、静脉自控镇痛(PCIA)或胸段硬膜外镇痛(tPDA)。采用视觉模拟量表每日三次测量患者自我报告的疼痛程度。分别计算从干预开始至术后第二天结束(T(0 - 2))和术后第七天(T(0 - 7))静息状态(R)和标准化身体活动期间(M)的曲线下面积(AUC)。
腹腔镜手术在T(0 - 2)静息状态下的AUC中位数(13)比侧腹切口(A组,9)更高,在身体活动期间两者大致相同。对于侧腹切口(A组),静息状态下T(0 - 2)的AUC中位数从9升至T(0 - 7)的22,在身体活动时AUC中位数从18增至37。相比之下,腹腔镜手术后第二天之后未引起进一步疼痛。此外,对于侧腹切口T(0 - 2),在静息状态下,tPDA优于A组(AUC中位数:5对9,p = 0.02),在身体活动时tPDA(AUC中位数:12)的疼痛控制效果也优于A组(18)甚至PCIA组(19,p = 0.005)。
腹腔镜肾切除术在T(0 - 2)期间会引起相对强烈的平均累积疼痛,随后疼痛消失。然而,侧腹切口术后疼痛水平持续升高直至术后第七天,tPDA是最有效的治疗方法。