Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, People's Republic of China.
Department of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing 100191, People's Republic of China.
Br J Nutr. 2019 Nov 14;122(9):1033-1039. doi: 10.1017/S0007114519001727.
We aimed to investigate the trends of breast milk lutein concentrations at different times and their relationship with dietary lutein intake during the 12 weeks after delivery. Breast milk samples were collected from thirty-seven mothers at 4, 8 and 12 weeks postpartum. A HPLC detection method was used to measure breast milk lutein concentrations. Dietary intake was assessed using an FFQ, and then dietary lutein intake was calculated. The correlations between dietary lutein intake and breast milk lutein concentrations during lactation were investigated by Pearson's correlation coefficient. General linear regression models were used to evaluate the optimal regression equation. The mean values of dietary lutein intake at 4, 8 and 12 weeks postpartum were 5·22 (sd 3·60), 7·28 (sd 4·30) and 7·33 (sd 4·24) mg/d, respectively. The mean values of breast milk lutein concentrations at 4, 8 and 12 weeks postpartum were as follows: 46·41 (sd 41·36), 57·96 (sd 40·00) and 62·33 (sd 30·10) μg/l, respectively. Breast milk lutein concentrations were positively associated with dietary lutein intake at 4 weeks postpartum (r 0·527, P < 0·05), which was consistent with the positive correlations observed at 8 and 12 weeks postpartum (r 0·444, P < 0·05; r 0·468, P < 0·05) by the sensitivity analysis. Increased dietary lutein intake can increase the concentration of lutein in the breast milk, and women are recommended to increase their dietary intake of green leafy vegetables and fruits that are rich in lutein during the pregnancy and postpartum periods.
本研究旨在探讨哺乳期不同时间点母乳中叶黄素浓度的变化趋势及其与产后 12 周内饮食中叶黄素摄入量的关系。共采集 37 名产妇产后 4、8 和 12 周的母乳样本，采用高效液相色谱法检测母乳中叶黄素浓度，使用食物频数问卷法评估产妇的饮食摄入情况，计算饮食中叶黄素摄入量。采用 Pearson 相关系数分析哺乳期饮食中叶黄素摄入量与母乳中叶黄素浓度的相关性，采用广义线性回归模型分析评估最佳回归方程。结果显示，产妇产后 4、8 和 12 周的饮食叶黄素摄入量分别为 5·22（sd 3·60）、7·28（sd 4·30）和 7·33（sd 4·24）mg/d，母乳中叶黄素浓度分别为 46·41（sd 41·36）、57·96（sd 40·00）和 62·33（sd 30·10）μg/L。产后 4 周时，母乳中叶黄素浓度与饮食中叶黄素摄入量呈正相关（r 0·527，P < 0·05），8 周和 12 周时的敏感性分析结果也显示两者呈正相关（r 0·444，P < 0·05；r 0·468，P < 0·05）。提示增加饮食中叶黄素的摄入可以提高母乳中叶黄素的浓度，建议女性在孕期和哺乳期增加富含叶黄素的绿叶蔬菜和水果的摄入。
