Lee Eun, Suh Dong In, Lee So-Yeon, Jung Sungsu, Yoon Sungsu Jisun, Cho Hyun-Ju, Kim Youngho, Yang Song-I, Kwon Ji-Won, Jang Gwang Cheon, Sun Yong Han, Woo Sung-Il, Youn You-Sook, Park Kang Seo, Cho Hwa Jin, Kook Myung-Hee, Yi Hye Ryoung, Chung Hai Lee, Kim Ja-Hyeong, Kim Hyung Young, Jung Jin A, Woo Hyang-Ok, Lee Jeom-Kyu, Chang Woo-Sung, Hong Soo-Jong
Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.
Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
Asian Pac J Allergy Immunol. 2021 Dec;39(4):231-240. doi: 10.12932/AP-201218-0464.
Sensitization is associated with the exacerbation, severity, and prognosis of allergic diseases in children.
We characterized the association between sensitization patterns and allergic diseases.
A cohort of 548 children was enrolled from Panel Study of Korean Children (PSKC) study. Skin prick tests (SPTs) for 18 common allergens, blood tests, and methacholine bronchial challenge tests were performed at age 7. The Korean version of International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used.
The sensitization rate on SPTs was 46.4%. Sensitization to indoor allergens showed an association with symptoms of asthma (adjusted odds ratio [aOR], 2.39; 95% confidence intervals [95% CIs], 1.10-5.23), allergic rhinitis (AR, aOR 2.08, 95% CIs 1.42-3.06), and atopic dermatitis (AD, aOR 2.36, 95% CIs 1.24-4.50) in the preceding 12 months. In contrast, sensitization to outdoor allergens was associated with AR diagnosis only (aOR 2.40, 95% CIs 1.30-4.41). The number of sensitized allergens was associated with a lifetime diagnosis and symptoms in the preceding 12 months of AR and asthma, but not with AD or BHR. A higher degree of sensitization to indoor allergens was associated with symptoms in the preceding 12 months of asthma, AR, AD, and that for outdoor allergens was associated with symptoms in the prior 12 months of asthma and AR.
The sensitization patterns including allergen type, number, and degree of sensitization are helpful for interpreting the association between sensitization and allergic diseases and identifying the pathophysiologies and diverse phenotypes of allergic diseases.
致敏作用与儿童过敏性疾病的加重、严重程度及预后相关。
我们对致敏模式与过敏性疾病之间的关联进行了特征描述。
从韩国儿童面板研究（PSKC）中纳入了548名儿童队列。在7岁时进行了针对18种常见过敏原的皮肤点刺试验（SPT）、血液检查和乙酰甲胆碱支气管激发试验。使用了儿童哮喘和过敏国际研究（ISAAC）问卷的韩语版本。
SPT的致敏率为46.4%。对室内过敏原的致敏与前12个月内哮喘症状（校正比值比[aOR]，2.39；95%置信区间[95%CI]，1.10 - 5.23）、过敏性鼻炎（AR，aOR 2.08，95%CI 1.42 - 3.06）和特应性皮炎（AD，aOR 2.36，95%CI 1.24 - 4.50）相关。相比之下，对室外过敏原的致敏仅与AR诊断相关（aOR 2.40，95%CI 1.30 - 4.41）。致敏过敏原的数量与AR和哮喘前12个月的终生诊断及症状相关，但与AD或支气管高反应性无关。对室内过敏原更高程度的致敏与哮喘、AR、AD前12个月的症状相关，而对室外过敏原的致敏与哮喘和AR前12个月的症状相关。
包括过敏原类型、数量和致敏程度的致敏模式有助于解释致敏与过敏性疾病之间的关联，并识别过敏性疾病的病理生理学和多种表型。
