Emerg Infect Dis. 2019 Aug;25(8):1452-1460. doi: 10.3201/eid2508.180915.
We report demographic, epidemiologic, and clinical findings for a prospective cohort of pregnant women during the initial phase of Zika virus introduction into Yucatan, Mexico. We monitored 115 pregnant women for signs of active or recent Zika virus infection. The estimated cumulative incidence of Zika virus infection was 0.31 and the ratio of symptomatic to asymptomatic cases was 1.7 (range 1.3-4.0 depending on age group). Exanthema was the most sensitive clinical sign but also the least specific. Conjunctival hyperemia, joint edema, and exanthema were the combination of signs that had the highest specificity but low sensitivity. We did not find evidence of vertical transmission or fetal anomalies, likely because of the low number of pregnant women tested. We also did not find evidence of congenital disease. Our findings emphasize the limited predictive value of clinical features in areas where Zika virus cocirculates with other flaviviruses.
我们报告了在墨西哥尤卡坦州寨卡病毒初次传入期间，前瞻性孕妇队列的人口统计学、流行病学和临床发现。我们监测了 115 名孕妇是否有寨卡病毒感染的迹象。寨卡病毒感染的估计累积发病率为 0.31，有症状与无症状病例的比例为 1.7（取决于年龄组，范围为 1.3-4.0）。出疹是最敏感的临床体征，但特异性最低。结膜充血、关节肿胀和出疹是特异性最高但敏感性最低的组合体征。我们没有发现垂直传播或胎儿异常的证据，可能是因为接受检测的孕妇数量较少。我们也没有发现先天性疾病的证据。我们的发现强调了在寨卡病毒与其他黄病毒共同传播的地区，临床特征的预测价值有限。
