Regional Research Center Hideyo Noguchi, Universidad Autonoma de Yucatan, Merida, Mexico.
Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, Florida.
Am J Trop Med Hyg. 2018 Apr;98(4):1202-1208. doi: 10.4269/ajtmh.17-0382. Epub 2018 Feb 15.
Dengue transmission in Mexico has become a major public health problem. Few epidemiological studies have examined the seroprevalence of dengue in Mexico, and recent estimates are needed to better understand dengue transmission dynamics. We conducted a dengue seroprevalence survey among 1,668 individuals including all age groups in three urban settings in Yucatan, Mexico. Children (< 19 years old) were selected randomly from schools. The adults (≥ 19 years old) were selected from healthcare facilities. Participants were asked to provide a venous blood sample and to answer a brief questionnaire with demographic information. Previous exposure to dengue was determined using indirect immunoglobulin G enzyme-linked immunosorbent assay. The overall seroprevalence was 73.6%. The age-specific seroprevalence increased with age, going from 51.4% (95% confidence interval [CI] = 45.0-57.9%) in children ≤ 8 years to 72% (95% CI = 66.3-77.2%) in the 9- to 14-years old. The highest seroprevalence was 83.4% (95% CI = 77-82.2%) in adults greater than 50 years. The seroprevalence in Merida was 68.6% (95% CI = 65-72%), in Progreso 68.7% (95% CI = 64.2-72.8%), and in Ticul 85.3% (95% CI = 81.9-88.3%). Ticul had the highest seroprevalence in all age groups. Logistic regression analysis showed that age and city of residence were associated with greater risk of prior dengue exposure. The results highlight the level of past exposure to dengue virus including young children. Similar studies should be conducted elsewhere in Mexico and other endemic countries to better understand the transmission dynamics of dengue.
墨西哥的登革热传播已成为一个主要的公共卫生问题。很少有流行病学研究调查过墨西哥的登革热血清流行率，因此需要进行最新估计，以更好地了解登革热传播动态。我们在墨西哥尤卡坦的三个城市环境中对包括所有年龄段在内的 1668 人进行了登革热血清流行率调查。儿童（<19 岁）是从学校随机选择的。成年人（≥19 岁）是从医疗机构选择的。参与者被要求提供静脉血样，并回答一份简短的问卷，内容包括人口统计学信息。使用间接免疫球蛋白 G 酶联免疫吸附试验来确定以前是否接触过登革热。总体血清流行率为 73.6%。年龄特异性血清流行率随年龄增长而增加，从 8 岁以下儿童的 51.4%（95%置信区间[CI] = 45.0-57.9%）到 9-14 岁儿童的 72%（95% CI = 66.3-77.2%）。50 岁以上成年人的血清流行率最高，为 83.4%（95% CI = 77-82.2%）。梅里达的血清流行率为 68.6%（95% CI = 65-72%），普罗格雷索为 68.7%（95% CI = 64.2-72.8%），蒂基尔为 85.3%（95% CI = 81.9-88.3%）。在所有年龄组中，蒂基尔的血清流行率最高。逻辑回归分析表明，年龄和居住地与以前接触登革热的风险增加有关。研究结果突出了过去接触登革热病毒的程度，包括儿童。在墨西哥其他地区和其他流行地区应进行类似的研究，以更好地了解登革热的传播动态。
