Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat 382481, India.
Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, India.
J Control Release. 2019 Aug 28;308:130-161. doi: 10.1016/j.jconrel.2019.07.016. Epub 2019 Jul 13.
Graphene based nanocomposites have revolutionized cancer treatment, diagnosis and imaging owing to its good compatibility, elegant flexibility, high surface area, low mass density along with excellent combined additive effect of graphene with other nanomaterials. This review inculcates the type of graphene based nanocomposites and their fabrication techniques to improve its properties as photothermal and theranostic platform. With decades' efforts, many significant breakthroughs in the method of synthesis and characterization in addition to various functionalization options of graphene based nanocomposite have paved a solid foundation for their potential applications in the cancer therapy. This work intends to provide a thorough, up-to-date holistic discussion on correlation of breakthroughs with their biomedical applications and illustrate how to utilize these breakthroughs to address long-standing challenges in the clinical translation of nanomedicines. This review also emphasizes on graphene based nanocomposites based toxicity concerns pertaining to delivery platforms.
基于石墨烯的纳米复合材料由于其良好的相容性、优雅的灵活性、高表面积、低质量密度以及与其他纳米材料的协同附加效应，彻底改变了癌症的治疗、诊断和成像。本综述介绍了基于石墨烯的纳米复合材料的类型及其制造技术，以改善其作为光热和治疗学平台的性能。经过几十年的努力，在合成和表征方法以及基于石墨烯的纳米复合材料的各种功能化选择方面都取得了许多重大突破，为它们在癌症治疗中的潜在应用奠定了坚实的基础。这项工作旨在提供一个全面、最新的综合讨论，阐述这些突破与其生物医学应用的相关性，并说明如何利用这些突破来解决纳米医学临床转化中的长期挑战。本综述还强调了与基于石墨烯的纳米复合材料相关的毒性问题。
