Kılıç Alparslan
Department of Cardiology, Ankara Training and Research Hospital, Ankara, Turkey.
Turk Kardiyol Dern Ars. 2019 Jul;47(5):373-378. doi: 10.5543/tkda.2019.92428.
Pulse wave velocity (PWV) is the primary determiner of arterial stiffness. In daily practice, the normal range of arterial stiffness is based on large multi-center studies conducted in the USA, Europe, Asia, and Australia. The goal of this study was to identify the reference values of brachial PWV in a healthy, normotensive Turkish population with no cardiovascular risk factors.
This retrospective study involved healthy, adult Turkish participants from Ankara. A total of 353 consecutive, normotensive individuals were enrolled in the study between September 2017 and January 2018 according to strict inclusion criteria, Normal PWV and 95% confidence interval values were acquired for 353 patients (mean age: 55.03±15.38 years; range: 20-95 years) who were divided into 6 age groups.
The mean PWV was 7.75±1.89 m/s (range: 4.25- 15.90 m/s). The PWV had a positive linear correlation with age (r2=0.94; p=0.00). The PWV increased gradually by an average of 5% to 9% with each decade of life until the age of 50 years, after which the average PWV increased by 16%.
To the best of our knowledge, this study is the first to define PWV reference values via brachial measurement in a healthy, normotensive Turkish population. These data provide important information for daily clinical practice in Turkey.
脉搏波速度（PWV）是动脉僵硬度的主要决定因素。在日常实践中，动脉僵硬度的正常范围基于在美国、欧洲、亚洲和澳大利亚进行的大型多中心研究。本研究的目的是确定在无心血管危险因素的健康、血压正常的土耳其人群中肱动脉PWV的参考值。
这项回顾性研究纳入了来自安卡拉的健康成年土耳其参与者。根据严格的纳入标准，在2017年9月至2018年1月期间，共有353名连续的血压正常个体被纳入研究。为353名患者（平均年龄：55.03±15.38岁；范围：20 - 95岁）获取了正常PWV和95%置信区间值，这些患者被分为6个年龄组。
平均PWV为7.75±1.89米/秒（范围：4.25 - 15.90米/秒）。PWV与年龄呈正线性相关（r2 = 0.94；p = 0.00）。在50岁之前，PWV每十年平均逐渐增加5%至9%，50岁之后，平均PWV增加16%。
据我们所知，本研究首次通过肱动脉测量确定了健康、血压正常的土耳其人群的PWV参考值。这些数据为土耳其的日常临床实践提供了重要信息。
