Marinho P E S, Kroon E G
Laboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
New Microbes New Infect. 2019 May 25;31:100572. doi: 10.1016/j.nmni.2019.100572. eCollection 2019 Sep.
Flaviviruses are agents of a major emerging human public health issue and members of this genus have been associated with central nervous system (CNS) infections. In Brazil, a country endemic for some arboviruses, the most clinically relevant neurotropic flaviviruses include Dengue virus and Zika virus. Flaviviruses cause diseases ranging from mild or sub-clinical infections to severe cases as CNS infections. There is a lack of data about the incidence of flaviviruses in the CNS of children in Brazil. In this review, we provide a general overview of several flaviviruses that cause CNS infections in Brazilian children and explore the importance of epidemiological surveillance of CNS infections in cases of flavivirus infections.
黄病毒是一个主要的新出现的人类公共卫生问题的病原体，该属成员与中枢神经系统（CNS）感染有关。在巴西这个一些虫媒病毒的流行国家，临床上最相关的嗜神经黄病毒包括登革病毒和寨卡病毒。黄病毒可引起从轻度或亚临床感染到严重的中枢神经系统感染等各种疾病。巴西儿童中枢神经系统中黄病毒感染率的数据匮乏。在本综述中，我们概述了几种可导致巴西儿童中枢神经系统感染的黄病毒，并探讨了在黄病毒感染病例中对中枢神经系统感染进行流行病学监测的重要性。
