Mulder Danielle Wingrove, Phiri Masauso Moses, Jordaan Anine, Vorster Barend Christiaan
Center for Human Metabolomics, North-West University, Hoffman street, Potchefstroom, South Africa.
Chemical Resource Beneficiation (CRB), North-West University, Potchefstroom, South Africa.
R Soc Open Sci. 2019 Jun 12;6(6):190160. doi: 10.1098/rsos.190160. eCollection 2019 Jun.
Gold nanostars are being used more regularly in the biosensing field. Despite their useful attributes, there is still a need to optimize aspects of the synthesis and stability. The seedless, synthetic method comprising 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) is a facile, rapid method; however, it produces heteromorphic nanostars. The modification of a HEPES method resulted in a silver-assisted, seedless gold nanostar synthesis method. The nanostars resulting from this method were monodispersed, multi-branched and approximately 37 ± 2 nm in diameter. It proved to be a repeatable method that produced homogeneous and robust nanostars. Once functionalized with polyvinylpyrrolidone 10 000, the new nanostars were observed to be stable in various environments such as salt, ionic strength and cell culture medium. In conclusion, the addition of the silver nitrate improved the morphology of the reported HEPES nanostars for the purpose of nanobiosensor development.
金纳米星在生物传感领域的应用越来越频繁。尽管它们具有有用的特性，但仍需要优化合成和稳定性方面。包含4-(2-羟乙基)-1-哌嗪乙磺酸（HEPES）的无籽合成方法是一种简便、快速的方法；然而，它会产生异形纳米星。对HEPES方法的改进产生了一种银辅助的无籽金纳米星合成方法。用这种方法得到的纳米星是单分散的、多分支的，直径约为37±2nm。事实证明，这是一种可重复的方法，能产生均匀且稳定的纳米星。一旦用10000的聚乙烯吡咯烷酮功能化，新的纳米星在盐、离子强度和细胞培养基等各种环境中都被观察到是稳定的。总之，为了纳米生物传感器的开发，添加硝酸银改善了所报道的HEPES纳米星的形态。
