Fu Jie, Yang Xiaojing
Radiation Oncology, Shanghai Jiao Tong University Affliated Sixth People's Hospital, Shanghai, CHN.
Cureus. 2019 May 12;11(5):e4648. doi: 10.7759/cureus.4648.
Objective Patients with advanced laryngeal cancer have a poor prognosis. The purpose of this work was to analyze the connection between clinical factors and survival and to try to identify survival prognostic factors. Methods Sixty-one laryngeal cancer patients received radiotherapy. All of their clinicopathologic material was gathered from a retrospective review of the medical records and subjected to further analysis. We examined the prognostic significance of the C-reactive protein (CRP)/prognostic nutritional index (PNI) ratio. Results We assessed the CRP and PNI levels before radiotherapy. An analysis of overall survival (OS) of patients with high CRP/PNI was markedly shorter than for those patients with a low CRP/PNI (P=0.010). Multivariable analysis showed that a high CRP/PNI ratio was a disadvantageous independent prognostic marker. Conclusions The data show that CRP/PNI may be used as a prognostic indicator for laryngeal cancer patients treated with radiotherapy.
目的 晚期喉癌患者预后较差。本研究旨在分析临床因素与生存率之间的关联，并尝试确定生存预后因素。方法 61例喉癌患者接受了放射治疗。所有患者的临床病理资料均通过回顾病历进行收集，并进行进一步分析。我们检测了C反应蛋白（CRP）/预后营养指数（PNI）比值的预后意义。结果 我们在放疗前评估了CRP和PNI水平。高CRP/PNI患者的总生存期（OS）分析显示明显短于低CRP/PNI患者（P = 0.010）。多变量分析表明，高CRP/PNI比值是一个不利的独立预后标志物。结论 数据表明，CRP/PNI可作为接受放射治疗的喉癌患者的预后指标。
