载前列环素类似物的纳米颗粒减轻大鼠心肌缺血/再灌注损伤

Prostacyclin Analogue-Loaded Nanoparticles Attenuate Myocardial Ischemia/Reperfusion Injury in Rats.

作者信息

Yajima Shin, Miyagawa Shigeru, Fukushima Satsuki, Sakai Yoshiki, Iseoka Hiroko, Harada Akima, Isohashi Kayako, Horitsugi Genki, Mori Yuki, Shiozaki Motoko, Ohkawara Hirotatsu, Sakaniwa Ryoto, Hatazawa Jun, Yoshioka Yoshichika, Sawa Yoshiki

机构信息

Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.

Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Osaka, Japan.

出版信息

JACC Basic Transl Sci. 2019 May 8;4(3):318-331. doi: 10.1016/j.jacbts.2018.12.006. eCollection 2019 Jun.

Intravenously injected ONO-1301-containing nanoparticles (ONO-1301NPs), unlike an ONO-1301 solution, selectively accumulated in the ischemia/reperfusion (I/R)-injured myocardium of rats and contributed to the prolonged retention of ONO-1301 in the targeted myocardial tissue. In the ischemic area, proangiogenic cytokines were up-regulated and inflammatory cytokines were down-regulated upon ONO-1301NP administration. Consequently, ONO-1301NP-injected rats exhibited a smaller infarct size, better-preserved capillary networks, and a better-preserved myocardial blood flow at 24 h after I/R injury, compared with those in vehicle-injected or ONO-1301 solution-injected rats. ONO-1301NPs attenuate the myocardial I/R injury via proangiogenic and anti-inflammatory effects of the drug.