Children's Research Institute, Xi'an Key Laboratory of Children's Health and Diseases, Affiliated Children Hospital, Xi'an Jiaotong University, 69# Xijuyuan Lane, Lianhu District, Xi'an, 710003, Shaanxi, China.
Inflamm Res. 2019 Oct;68(10):815-823. doi: 10.1007/s00011-019-01269-1. Epub 2019 Jul 16.
C-reactive protein (CRP) is a non-specific diagnostic marker of inflammation and an evolutionarily conserved protein with roles in innate immune signaling. Natural CRP is composed of five identical globular subunits that form a pentamer, but the role of pentameric CRP (pCRP) during inflammatory pathogenesis remains controversial. Emerging evidence suggests that pCRP can be dissociated into monomeric CRP (mCRP) that has major roles in host defenses and inflammation. Here, we discuss our current knowledge of the dissociation mechanisms of pCRP and summarize the stepwise conformational transition model to mCRP to elucidate how CRP dissociation contributes to proinflammatory activity. These discussions will evoke new understanding of this ancient protein.
C 反应蛋白（CRP）是炎症的非特异性诊断标志物，也是一种进化上保守的蛋白质，在先天免疫信号中发挥作用。天然 CRP 由五个相同的球形亚基组成，形成五聚体，但 pCRP（五聚体 CRP）在炎症发病机制中的作用仍存在争议。新出现的证据表明，pCRP 可以解离为单体 CRP（单体 CRP），在宿主防御和炎症中发挥主要作用。在这里，我们讨论了我们目前对 pCRP 解离机制的了解，并总结了 CRP 向 mCRP 逐步构象转变的模型，以阐明 CRP 解离如何促进促炎活性。这些讨论将唤起对这种古老蛋白质的新认识。
