Deza Gustavo, Vidal Ainhoa, Gallardo Fernando, Iranzo Pilar, Canal de la Iglesia Laia, Pujol Ramon M
Department of Dermatology, Hospital del Mar Institut Mar d'Investigacions Mèdiques, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
Department of Dermatology, Hospital Clínic, Universitat de Barcelona (UB), Barcelona, Spain; and.
Am J Dermatopathol. 2020 Feb;42(2):e22-e25. doi: 10.1097/DAD.0000000000001495.
Herein, we report a case of an adult male patient with a chronic and recurrent papulopustular eruption mainly involving the trunk and lower extremities. A dense superficial perifollicular inflammatory infiltrate with palisading necrobiotic granuloma formation and infundibular perforation was observed at the histological examination, with no granulomatous inflammatory infiltrates in deeper areas. The possibility that this peculiar clinicopathological presentation constitutes a case of generalized perforating granuloma annulare (PGA) or an individualized skin condition is discussed. The observation of a pustular follicular generalized PGA represents an exceedingly rare phenomenon and constitutes an infrequent subtype of PGA that can mimic pustular eruptions secondary to many different etiologies. The clinicopathological features of this rare variant may represent a diagnostic challenge, often requiring multiple biopsies to establish a definite diagnosis.
在此，我们报告一例成年男性患者，其患有慢性复发性丘疹脓疱性皮疹，主要累及躯干和下肢。组织学检查发现密集的浅表毛囊周围炎性浸润，伴有栅栏状坏死性肉芽肿形成和漏斗部穿孔，深部区域无肉芽肿性炎性浸润。讨论了这种特殊的临床病理表现构成泛发性穿通性环状肉芽肿（PGA）病例或一种个体化皮肤疾病的可能性。脓疱性毛囊泛发性PGA的观察是一种极其罕见的现象，是PGA的一种罕见亚型，可模仿多种不同病因引起的脓疱性皮疹。这种罕见变体的临床病理特征可能构成诊断挑战，通常需要多次活检才能确诊。
