Gamo Villegas R, Sopena Barona J, Guerra Tapia A, Vergara Sanchez A, Rodríguez Peralto J L, Iglesias DIez L
Department of Dermatology, Hospital 12 de Octubre, Avda de Andalucía Km 5.400, 28041 Madrid, Spain.
Br J Dermatol. 2003 Oct;149(4):866-8. doi: 10.1046/j.1365-2133.2003.05655.x.
We report a 84-year-old man with a 13-year history of recurrent generalized asymptomatic pustular lesions. Histology revealed areas of necrobiosis surrounded by palisading granulomas and transepidermal and follicular elimination of the necrobiotic material. A dense infiltrate of neutrophils was also found. Although 26% of patients with generalized perforating granuloma annulare have some yellow pustule-like papules, these correspond histologically to the yellow viscous necrobiotic material extruding through the epidermis and not to a real neutrophilic infiltrate. This is the first case report of perforating granuloma annulare with recurrent generalized pustular lesions with a dense infiltrate of neutrophils.
我们报告一名84岁男性，有13年复发性全身性无症状脓疱性皮损病史。组织学检查显示有坏死区，周围有栅栏状肉芽肿，坏死物质经表皮和毛囊排出。还发现有密集的中性粒细胞浸润。虽然26%的泛发性穿通性环状肉芽肿患者有一些黄色脓疱样丘疹，但这些在组织学上对应于通过表皮挤出的黄色粘性坏死物质，而非真正的中性粒细胞浸润。这是首例关于泛发性穿通性环状肉芽肿伴复发性全身性脓疱性皮损及密集中性粒细胞浸润的病例报告。
