Kofler R
Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037.
J Immunol. 1988 Jun 1;140(11):4031-4.
A novel murine VH gene family, termed VH10, has been found and characterized. Based on RFLP analysis, this family exhibits extensive polymorphism among inbred strains of mice and encompasses two to five members, depending on the Igh haplotype. Analyses of recombinant inbred strains suggest a map position of this family 5' to the 7183 and Q52 VH gene families. A VH10 gene has been found to encode anti-DNA autoantibodies from lupus mice; another one may be a pseudogene.
已发现并鉴定出一个名为VH10的新型小鼠VH基因家族。基于限制性片段长度多态性（RFLP）分析，该家族在近交系小鼠中表现出广泛的多态性，并且根据免疫球蛋白重链（Igh）单倍型包含两到五个成员。对重组近交系的分析表明，该家族的图谱位置在7183和Q52 VH基因家族的5'端。已发现一个VH10基因可编码狼疮小鼠的抗DNA自身抗体；另一个可能是假基因。
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