Luo Hua, Qin Guangmei, Yao Caoyuan
Department of Respiratory Medicine, Yongchuan Hospital, Chongqing Medical University, Chongqing, China.
J Int Med Res. 2019 Aug;47(8):3522-3533. doi: 10.1177/0300060519858012. Epub 2019 Jul 18.
To determine the association between the multidrug resistance 1 gene () C3435T polymorphism and adverse drug reactions in advanced non-small cell lung cancer (NSCLC) patients in Asia.
Literature about the relationship between the C3435T polymorphism and adverse drug reactions in advanced NSCLC patients were collected from three English language databases (PubMed, Cochrane, and Embase) as well as three Chinese databases (Wanfang, China Knowledge Network, and the Chinese Biomedical Literature Database), and summarized by a meta-analysis.
NSCLC patients with the T allele or TT genotype were significantly more likely to experience diarrhea than those with other genotypes under the allele model (odds ratio [OR] = 1.64, 95% confidence interval [CI]: 1.04–2.61), homozygous model (OR = 3.87, 95% CI: 1.49–10.07), and recessive model (OR = 4.48, 95% CI: 1.88–10.68). Similarly, these patients were significantly more likely to experience skin rash under the allele model (OR = 2.41, 95% CI: 1.24–4.66), homozygous model (OR = 4.77, 95% CI: 1.13–20.15), and dominant model (OR = 1.77, 95% CI: 1.03–3.05).
Asian NSCLC patients with the C3435T T allele or TT genotype are significantly more likely to develop diarrhea and rash after drug treatment.
确定亚洲晚期非小细胞肺癌（NSCLC）患者多药耐药1基因（）C3435T多态性与药物不良反应之间的关联。
从三个英文数据库（PubMed、Cochrane和Embase）以及三个中文数据库（万方、中国知网和中国生物医学文献数据库）收集有关C3435T多态性与晚期NSCLC患者药物不良反应关系的文献，并进行荟萃分析总结。
在等位基因模型（优势比[OR]=1.64，95%置信区间[CI]：1.04–2.61）、纯合子模型（OR=3.87，95%CI：1.49–10.07）和隐性模型（OR=4.48，95%CI：1.88–10.68）下，携带T等位基因或TT基因型的NSCLC患者比其他基因型患者更易发生腹泻。同样，在等位基因模型（OR=2.41，95%CI：1.24–4.66）、纯合子模型（OR=4.77，95%CI：1.13–20.15）和显性模型（OR=1.77，95%CI：1.03–3.05）下，这些患者更易出现皮疹。
携带C3435T T等位基因或TT基因型的亚洲NSCLC患者在药物治疗后更易发生腹泻和皮疹。
