College of Public Health and Health Informatics, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
King Abdullah International Medical Research Center (KAIMRC), Riyadh, Saudi Arabia.
BMC Cancer. 2019 Jul 17;19(1):703. doi: 10.1186/s12885-019-5897-5.
Leukemia is a malignant neoplasm that arises from hematopoietic cells. The number of leukemia cases has dramatically increased from 297,000 to 437, 033 cases worldwide. As result, the the Saudi Cancer Registry ramked leukemia as the 5th type of cancer cases among both genders in Saudi Arabia. Data on the trend and incidence of leukemnia in Saudi Arabia is lacking. This study aims to report the trend and incidence of leukemia in Saudi Arabia using available data from the Saudi Cancer Registry (SCR), as a population-based cancer registry in the country over a period of 15 years (1999-2013).
Data of registered leukemia cases between years 1999-2013 were retrieved from the Saudi Council of Health, Saudi Cancer Registry. Data were coded using the International Classification of Diseases for Oncology (ICD-O). Main and essential variables were retrieved such as age, sex, years of incidence, residency, and histopathological type of leukemia.
A total of 8712 cases of leukemia were analyzed in this study, 57.2% were males and 42.8% were females. Around 33.6% of cases were from the central region of Saudi Arabia. The most diagnosed type of leukemia was the Precursor B-cell lymphoblastic leukemia (18.7%), followed by Precursor cell lymphoblastic leukemia, NOS (17.3%) with equal percentage of reported cases between males and females in these subsets.
Ove a period of 15 years, the trend of leukemia showed the likelihood of increase in rate particularly in males with highest incidence reported from the central region of Saudi Arabia which needs more investigation. Resources for diagnosis and treatment should be planned with more orientation toward the accurate diagnosis of leukemia to minimize the number of "none specific diagnosis".
白血病是一种起源于造血细胞的恶性肿瘤。全球白血病病例数从 29.7 万例急剧增加到 43.7033 万例。因此，沙特癌症登记处将白血病列为沙特男女癌症病例的第 5 种类型。沙特缺乏有关白血病趋势和发病率的数据。本研究旨在利用沙特癌症登记处（SCR）的现有数据报告沙特的白血病趋势和发病率，该登记处是该国的一个基于人群的癌症登记处，时间跨度为 15 年（1999-2013 年）。
从沙特健康委员会、沙特癌症登记处检索 1999-2013 年登记的白血病病例数据。数据使用国际肿瘤疾病分类（ICD-O）进行编码。检索了主要和基本变量，如年龄、性别、发病年份、居住地和白血病的组织病理学类型。
本研究共分析了 8712 例白血病病例，其中 57.2%为男性，42.8%为女性。约 33.6%的病例来自沙特阿拉伯中部地区。诊断出的最常见类型的白血病是前体细胞 B 细胞淋巴母细胞白血病（18.7%），其次是前体细胞淋巴母细胞白血病，NOS（17.3%），男性和女性在这些亚组中的报告病例比例相等。
在 15 年期间，白血病的趋势显示出发病率增加的可能性，特别是在男性中，发病率最高的报告来自沙特阿拉伯中部地区，这需要进一步调查。应计划诊断和治疗资源，更多地针对白血病的准确诊断，以尽量减少“非特异性诊断”的数量。
