Cellular and Molecular Therapeutics Laboratory, Centre for Biomaterials, Cellular and Molecular Theranostics, Vellore Institute of Technology (VIT) University, Vellore, Tamil Nadu, 632014, India.
Cancer Gene Ther. 2020 May;27(5):270-279. doi: 10.1038/s41417-019-0124-8. Epub 2019 Jul 18.
Glioblastoma multiforme is a highly malignant primary brain tumour found in adults and is highlighted as the most devastating among all the other grades of glioma. Well-established standard treatment methods, such as chemotherapy, radiation and surgery, have resulted in modest improvement in the survival of patients. Hence, the arduous search for novel treatments backed by advancements in molecular biology still persists. Glioblastoma has many distinctive characteristics, which makes it a potential candidate for gene therapy. Gene therapy involves the delivery of genetic material of therapeutic use into tumour cells, which produces a specific antitumour response. Moreover, viruses stimulate a vigorous cytotoxic effect, they are easily modifiable and the inherent property of horizontal transfer of genetic material makes them valuable tools for genetic engineering. In this review, we have enlisted the various viral vectors employed in gene therapy for glioblastoma.
多形性胶质母细胞瘤是一种在成人中发现的高度恶性原发性脑肿瘤，是所有其他胶质瘤等级中最具破坏性的。已确立的标准治疗方法，如化疗、放疗和手术，仅使患者的生存率略有提高。因此，人们仍在不懈地寻找新的治疗方法，并在分子生物学的进步方面得到支持。胶质母细胞瘤有许多独特的特征，使其成为基因治疗的潜在候选者。基因治疗包括将治疗用遗传物质递送至肿瘤细胞，从而产生特定的抗肿瘤反应。此外，病毒会刺激强烈的细胞毒性作用，它们易于修饰，并且遗传物质水平转移的固有特性使它们成为基因工程的有价值工具。在本综述中，我们列出了用于胶质母细胞瘤基因治疗的各种病毒载体。
