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克服血脑屏障，实现恶性脑肿瘤治疗：药物递送方法的现状与展望。

Overcoming the blood-brain barrier for the therapy of malignant brain tumor: current status and prospects of drug delivery approaches.

机构信息

Peter The Great St. Petersburg Polytechnic University, Polytechnicheskaya 29, St. Petersburg, 195251, Russian Federation.

School of Physics and Engineering, ITMO University, Lomonosova 9, St. Petersburg, 191002, Russian Federation.

出版信息

J Nanobiotechnology. 2022 Sep 15;20(1):412. doi: 10.1186/s12951-022-01610-7.

DOI:10.1186/s12951-022-01610-7
PMID:36109754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9479308/
Abstract

Besides the broad development of nanotechnological approaches for cancer diagnosis and therapy, currently, there is no significant progress in the treatment of different types of brain tumors. Therapeutic molecules crossing the blood-brain barrier (BBB) and reaching an appropriate targeting ability remain the key challenges. Many invasive and non-invasive methods, and various types of nanocarriers and their hybrids have been widely explored for brain tumor treatment. However, unfortunately, no crucial clinical translations were observed to date. In particular, chemotherapy and surgery remain the main methods for the therapy of brain tumors. Exploring the mechanisms of the BBB penetration in detail and investigating advanced drug delivery platforms are the key factors that could bring us closer to understanding the development of effective therapy against brain tumors. In this review, we discuss the most relevant aspects of the BBB penetration mechanisms, observing both invasive and non-invasive methods of drug delivery. We also review the recent progress in the development of functional drug delivery platforms, from viruses to cell-based vehicles, for brain tumor therapy. The destructive potential of chemotherapeutic drugs delivered to the brain tumor is also considered. This review then summarizes the existing challenges and future prospects in the use of drug delivery platforms for the treatment of brain tumors.

摘要

除了广泛发展用于癌症诊断和治疗的纳米技术方法外，目前在治疗不同类型的脑肿瘤方面还没有重大进展。治疗分子穿过血脑屏障（BBB）并达到适当的靶向能力仍然是关键挑战。许多侵袭性和非侵袭性方法以及各种类型的纳米载体及其混合物已被广泛探索用于脑肿瘤治疗。然而，不幸的是，迄今为止尚未观察到关键的临床转化。特别是，化疗和手术仍然是脑肿瘤治疗的主要方法。详细探索 BBB 穿透的机制并研究先进的药物输送平台是使我们更接近理解开发针对脑肿瘤的有效治疗方法的关键因素。在这篇综述中，我们讨论了 BBB 穿透机制的最相关方面，观察了药物输送的侵袭性和非侵袭性方法。我们还回顾了用于脑肿瘤治疗的功能性药物输送平台的最新进展，从病毒到基于细胞的载体。还考虑了递送到脑肿瘤的化疗药物的破坏性潜力。然后，该综述总结了在使用药物输送平台治疗脑肿瘤方面存在的挑战和未来展望。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e680/9479308/a2776a315a5b/12951_2022_1610_Fig13_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e680/9479308/711e242212bd/12951_2022_1610_Fig10_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e680/9479308/a2776a315a5b/12951_2022_1610_Fig13_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e680/9479308/995b0d43ba89/12951_2022_1610_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e680/9479308/2c790ba21487/12951_2022_1610_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e680/9479308/4442facf65dd/12951_2022_1610_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e680/9479308/dfbf22be2b62/12951_2022_1610_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e680/9479308/2359dc277e38/12951_2022_1610_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e680/9479308/685ebb4e35c1/12951_2022_1610_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e680/9479308/0eb7021ce72d/12951_2022_1610_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e680/9479308/ce7d57677468/12951_2022_1610_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e680/9479308/438c8abcde9c/12951_2022_1610_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e680/9479308/711e242212bd/12951_2022_1610_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e680/9479308/6bd20ea48efa/12951_2022_1610_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e680/9479308/f2504c9d25a7/12951_2022_1610_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e680/9479308/a2776a315a5b/12951_2022_1610_Fig13_HTML.jpg

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