Key Laboratory of Tropical Disease Control of the Ministry of Education, Sun Yat-sen University-Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Insect Pest Control Laboratory, Joint FAO/IAEA Programme of Nuclear Techniques in Food and Agriculture, Vienna International Centre, Vienna, Austria.
Nature. 2019 Aug;572(7767):56-61. doi: 10.1038/s41586-019-1407-9. Epub 2019 Jul 17.
The radiation-based sterile insect technique (SIT) has successfully suppressed field populations of several insect pest species, but its effect on mosquito vector control has been limited. The related incompatible insect technique (IIT)-which uses sterilization caused by the maternally inherited endosymbiotic bacteria Wolbachia-is a promising alternative, but can be undermined by accidental release of females infected with the same Wolbachia strain as the released males. Here we show that combining incompatible and sterile insect techniques (IIT-SIT) enables near elimination of field populations of the world's most invasive mosquito species, Aedes albopictus. Millions of factory-reared adult males with an artificial triple-Wolbachia infection were released, with prior pupal irradiation of the released mosquitoes to prevent unintentionally released triply infected females from successfully reproducing in the field. This successful field trial demonstrates the feasibility of area-wide application of combined IIT-SIT for mosquito vector control.
基于辐射的不育昆虫技术（SIT）已成功抑制了几种昆虫害虫的田间种群，但对蚊媒控制的效果有限。相关的不相容昆虫技术（IIT）——利用母体遗传的共生细菌沃尔巴克氏体引起的不育——是一种很有前途的替代方法，但如果意外释放与释放的雄性携带相同沃尔巴克氏体菌株的感染雌性，其效果可能会受到影响。在这里，我们表明，将不相容和不育昆虫技术（IIT-SIT）相结合，可以实现世界上最具入侵性的蚊子物种——白纹伊蚊的近乎彻底消除。数以百万计的经工厂饲养的成年雄性蚊子携带一种人工三重沃尔巴克氏体感染，在释放之前对释放的蚊子进行蛹期辐照，以防止意外释放的三重感染的雌性在野外成功繁殖。这项成功的现场试验证明了在蚊媒控制方面广泛应用组合 IIT-SIT 的可行性。
