mTOR作为寿命和衰老的核心调节因子。

Papadopoli David, Boulay Karine, Kazak Lawrence, Pollak Michael, Mallette Frédérick A, Topisirovic Ivan, Hulea Laura

Lady Davis Institute, SMBD JGH, 3755 Chemin de la Côte-Sainte-Catherine, Montréal, QC, H3T 1E2, Canada.

Gerald Bronfman Department of Oncology, McGill University, 5100 de Maisonneuve Blvd. West, Suite 720, Montréal, QC, H4A 3T2, Canada.

F1000Res. 2019 Jul 2;8. doi: 10.12688/f1000research.17196.1. eCollection 2019.

The mammalian/mechanistic target of rapamycin (mTOR) is a key component of cellular metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and proliferation. Although the involvement of the mTOR pathway in regulating life span and aging has been studied extensively in the last decade, the underpinning mechanisms remain elusive. In this review, we highlight the emerging insights that link mTOR to various processes related to aging, such as nutrient sensing, maintenance of proteostasis, autophagy, mitochondrial dysfunction, cellular senescence, and decline in stem cell function.

雷帕霉素的哺乳动物/机制性靶点（mTOR）是细胞代谢的关键组成部分，它将营养感知与推动细胞生长和增殖的细胞过程整合在一起。尽管在过去十年中，mTOR通路在调节寿命和衰老方面的作用已得到广泛研究，但其潜在机制仍不清楚。在这篇综述中，我们重点介绍了将mTOR与各种衰老相关过程联系起来的新见解，如营养感知、蛋白质稳态维持、自噬、线粒体功能障碍、细胞衰老以及干细胞功能衰退。