黄斑裂孔反复自发性闭合的病例系列

Elhusseiny Abdelrahman M, Smiddy William E, Flynn Harry W, Schwartz Stephen G

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 900 NW 17 Street, Miami, FL 33136, USA.

Department of Ophthalmology, Kasr Al Ainy School of Medicine, Cairo University, Egypt.

Case Rep Ophthalmol Med. 2019 Jun 16;2019:2398342. doi: 10.1155/2019/2398342. eCollection 2019.

Macular hole can undergo spontaneous reopening and reclosure. This is a retrospective review of three patients who had spontaneous reopening and reclosure of previously spontaneously closed macular hole documented by optical coherence tomography. We report the first case of nivolumab-uveitis-associated macular hole formation. The authors hypothesize that cystoid macular edema (CME) might alter the integrity of foveal tissues or conversely the orientation of the macular hole edges and play a role in formation and resolution of a macular hole.

黄斑裂孔可经历自发再开放和再闭合。这是一项对三名患者的回顾性研究，他们之前自发闭合的黄斑裂孔经光学相干断层扫描记录到出现了自发再开放和再闭合的情况。我们报告了首例与纳武单抗 - 葡萄膜炎相关的黄斑裂孔形成病例。作者推测，黄斑囊样水肿（CME）可能会改变黄斑中心凹组织的完整性，或者相反地改变黄斑裂孔边缘的方向，并在黄斑裂孔的形成和愈合过程中发挥作用。