Department of Ophthalmology, Faculty of Medicine, Benha University, Egypt.
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL.
Rom J Ophthalmol. 2020 Jul-Sep;64(3):285-291.
To describe the central three-dimensional (3D) thickness profile of the macula (CMT) and the subfoveal choroidal region (SFCT) in diabetic retinopathy (DR) following panretinal laser photocoagulation (PRP) using swept-source optical coherence tomography (SS-OCT). A prospective observational study including 17 eyes with proliferative DR (PDR) and 27 eyes with severe nonproliferative DR (sNPDR)] for whom PRP was done. All subjects received SS-OCT imaging before and 3 months after PRP (POM#3). SFCT and CMT changes were analysed at both visits. Intraclass Correlation Coefficients (ICC) and Coefficients of Variation (COV) were used to test the accuracy of thickness data. SFCT has thinned from 233 ± 54 µm before PRP treatment to 216 ± 51 µm 3 months later (p < 0.001). Likewise, CMT declined at POM#3 as compared to pre-PRP status (p<0.001). SFCT was thinner in PDR before and at POM#3 (p<0.05) than sNPDR; whereas, no significant difference was observed in CMT between both groups in the two visits. No significant changes were found between groups in SFCT and CMT at POM#3. Regarding reliability, ICCSFCT=0.98 and ICCCMT=0.99. The COVs for CMT and SFCT were 5.03% and 5.91%, respectively. The mean SFCT and CMT decreased 3 months after PRP. We also reported reliability of SFCT measurements in DR using SS-OCT. SS = Swept-Source, TD = time domain, SD = spectral domain, FD = Fourier-domain, 3D = three-dimensional, 2D = two-dimensional.
描述糖尿病性视网膜病变（DR）经全视网膜激光光凝（PRP）治疗后黄斑中心 3 维（3D）厚度（CMT）和中心凹下脉络膜厚度（SFCT）的中央 3D 厚度轮廓。这是一项前瞻性观察性研究，纳入了 17 只增殖性糖尿病性视网膜病变（PDR）眼和 27 只严重非增殖性糖尿病性视网膜病变（sNPDR）眼，这些眼均接受了 PRP 治疗。所有患者在 PRP 治疗前（POM#1）和治疗后 3 个月（POM#3）均接受了扫频源光学相干断层扫描（SS-OCT）成像。在两次就诊时均分析了 SFCT 和 CMT 的变化。使用组内相关系数（ICC）和变异系数（COV）来测试厚度数据的准确性。SFCT 在 PRP 治疗前为 233±54µm，治疗后 3 个月为 216±51µm（p<0.001）。同样，CMT 在 POM#3 时较 PRP 治疗前下降（p<0.001）。PDR 患者的 SFCT 在治疗前和 POM#3 时均较 sNPDR 患者薄（p<0.05），而两组在两次就诊时的 CMT 均无明显差异。两组在 POM#3 时 SFCT 和 CMT 均无明显变化。关于可靠性，SFCT 的 ICC=0.98，CMT 的 ICC=0.99。CMT 和 SFCT 的 COV 分别为 5.03%和 5.91%。PRP 治疗后 3 个月，SFCT 和 CMT 平均值均下降。我们还报道了使用 SS-OCT 测量 DR 中 SFCT 的可靠性。SS=扫频源，TD=时域，SD=光谱域，FD=傅里叶域，3D=三维，2D=二维。
