Varshney Shailesh, Dwivedi Anshuman, Pandey Vibha
Department of Periodontology, School of Dental Sciences, Sharda University, Greater Noida, Uttar Pradesh, India.
Medi Q Health Care, V 67, Sector 12, Noida, Uttar Pradesh, India.
J Oral Biol Craniofac Res. 2019 Oct-Dec;9(4):299-305. doi: 10.1016/j.jobcr.2019.06.013. Epub 2019 Jun 27.
The aim of the current review was to outline the existing information related to antimicrobial properties of various platelet concentrates, as experimented in various in-vitro studies.
One of the most interesting recent landmarks in the field of biological therapy has been the discovery that platelets, in addition to being capable of releasing hundreds of proteins and growth factors, can also release immunomodulatory agents with antimicrobial activity. Several international research groups have reported antimicrobial activities in both human platelets and other types of platelet rich plasma preparations.
This review was carried-out pursuing a systematic approach. An electronic search was conducted on MEDLINE and GOOGLE SCHOLAR databases using suitable search terminologies. It included preclinical studies which assessed the antimicrobial activity of Autologous Platelet Concentrates(APC).Ten in-vitro studies and one animal study, which investigated APC effects on various microorganisms, were included. Almost in all the included in-vitro studies, it was found that complete breakdown of microbial load could not be achieved by any of the APC preparations but there occurred a reduction in the growth of microorganisms. Thus APCs displayed a bacteriostatic rather than bacteriocidal activity.The only animal study included in this review which had both in-vitro and in-vivo evaluation, also showed reduction of infection caused by different microorganisms.
Although the precise mechanism of synergy with microbial pathogens needs further validation, platelet concentrates proved to have antimicrobial properties.
本综述的目的是概述在各种体外研究中所实验的与各种血小板浓缩物抗菌特性相关的现有信息。
生物治疗领域最近最有趣的标志性进展之一是发现血小板除了能够释放数百种蛋白质和生长因子外，还能释放具有抗菌活性的免疫调节因子。几个国际研究小组报告了人血小板和其他类型富血小板血浆制剂中的抗菌活性。
本综述采用系统方法进行。使用合适的检索词在MEDLINE和谷歌学术数据库上进行了电子检索。它包括评估自体血小板浓缩物（APC）抗菌活性的临床前研究。纳入了十项体外研究和一项动物研究，这些研究调查了APC对各种微生物的影响。几乎在所有纳入的体外研究中，发现任何一种APC制剂都无法实现微生物负荷的完全分解，但微生物的生长出现了减少。因此，APC表现出抑菌而非杀菌活性。本综述中唯一一项同时进行了体外和体内评估的动物研究也显示，由不同微生物引起的感染有所减少。
尽管与微生物病原体协同作用的确切机制需要进一步验证，但血小板浓缩物被证明具有抗菌特性。
