Department of Radiotherapy, University Medical Center Utrecht, Utrecht, Netherlands.
Computational Imaging Group for MRI Diagnostics & Therapy, Centre for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands.
Magn Reson Med. 2019 Dec;82(6):2236-2247. doi: 10.1002/mrm.27906. Epub 2019 Jul 17.
The noise navigator is a passive way to detect physiological motion occurring in a patient through thermal noise modulations measured by standard clinical radiofrequency receive coils. The aim is to gain a deeper understanding of the potential and applications of physiologically induced thermal noise modulations.
Numerical electromagnetic simulations and MR measurements were performed to investigate the relative contribution of tissue displacement versus modulation of the dielectric lung properties over the respiratory cycle, the impact of coil diameter and position with respect to the body. Furthermore, the spatial motion sensitivity of specific noise covariance matrix elements of a receive array was investigated.
The influence of dielectric lung property variations on the noise variance is negligible compared to tissue displacement. Coil size affected the thermal noise variance modulation, but the location of the coil with respect to the body had a larger impact. The modulation depth of a 15 cm diameter stationary coil approximately 3 cm away from the chest (i.e. radiotherapy setup) was 39.7% compared to 4.2% for a coil of the same size on the chest, moving along with respiratory motion. A combination of particular noise covariance matrix elements creates a specific spatial sensitivity for motion.
The insight gained on the physical relations governing the noise navigator will allow for optimized use and development of new applications. An optimized combination of elements from the noise covariance matrix offer new ways of performing, e.g. motion tracking.
噪声导航仪是一种通过标准临床射频接收线圈测量的热噪声调制来检测患者生理运动的被动方式。目的是更深入地了解生理诱导热噪声调制的潜力和应用。
进行了数值电磁模拟和 MR 测量,以研究组织位移与呼吸周期中肺介电性质调制的相对贡献、线圈直径和相对于身体的位置的影响。此外,还研究了接收阵列特定噪声协方差矩阵元素的空间运动灵敏度。
与组织位移相比,介电肺性质变化对噪声方差的影响可以忽略不计。线圈尺寸会影响热噪声方差调制,但线圈相对于身体的位置影响更大。与胸部随呼吸运动移动的相同尺寸的线圈相比,离胸部约 3 厘米处的 15 厘米直径固定线圈的调制深度约为 39.7%,而相同尺寸的线圈的调制深度为 4.2%。特定噪声协方差矩阵元素的组合为运动创建了特定的空间灵敏度。
对控制噪声导航仪的物理关系的深入了解将允许优化使用和开发新的应用。噪声协方差矩阵元素的优化组合提供了执行运动跟踪等新方法的途径。