Gareev I F, Novicova L B, Beylerli O A
Federal State Budgetary Educational Institution of Higher Education 'Bashkir State Medical University' of the Ministry of Healthcare of the Russian Federation, Ufa, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2019;119(5):86-90. doi: 10.17116/jnevro201911905186.
High-grade glial tumors (also called high-grade gliomas) are the most aggressive primary brain neoplasms. Therefore, much attention is paid to understanding the pathogenesis, as well as to the development of new effective diagnostic and therapeutic methods. MicroRNAs are short non-coding RNAs, 18-22 nucleotides in length, which, as has already been shown, play a direct role in carcinogenesis. Circulating miRNAs are released into the extracellular space and can be in a stable state for a long time in most biological liquids, including blood serum and plasma. Circulating miRNAs are promising biomarkers with different expression profiles specific for various human disorders, including cancer diseases.There are many data showing that different profiles of circulating miRNAs, in particular in extracellular vesicles (EV), in human biological fluids are associated with numerous neoplastic processes, which indicates that miRNAs can be a truly new class of biomarkers for early diagnosis and prognosis of high-grade gliomas.
高级别胶质瘤（也称为高级别胶质细胞瘤）是最具侵袭性的原发性脑肿瘤。因此，人们十分关注其发病机制的研究以及新型有效诊断和治疗方法的开发。微小RNA是长度为18 - 22个核苷酸的短链非编码RNA，正如已经表明的那样，它们在肿瘤发生中起直接作用。循环微小RNA被释放到细胞外空间，并且在包括血清和血浆在内的大多数生物液体中可以长期处于稳定状态。循环微小RNA是有前景的生物标志物，具有针对各种人类疾病（包括癌症疾病）的不同表达谱。有许多数据表明，人类生物体液中循环微小RNA的不同谱，特别是细胞外囊泡（EV）中的，与众多肿瘤过程相关，这表明微小RNA可以成为高级别胶质瘤早期诊断和预后的真正新型生物标志物类别。
