Wang Hui, Yuan Xianhou, Zhou Zhangming, Hu Juntao, Zhang Tao, Hu Shengli, Luo Jie, Li Xinjian
Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, China.
Asian Pac J Cancer Prev. 2011;12(4):833-5.
Recently, altered expression levels of several microRNAs have been observed in gliomas, the most frequent primary brain tumor in adults. To review whether microRNAs might be promising biomarkers of human gliomas, we comprehensively searched the Cochrane Library, Medline and EMbase from 1966 to 2010 with the language limitation of English. We found that further understanding of the functions of miRNAs in specific cellular events is needed; the continuous technological advances in accurate and cost-effective miRNAs detection provide the prospect of a very promising role for miRNAs as novel diagnostic biomarkers of gliomas.
最近，在胶质瘤（成人中最常见的原发性脑肿瘤）中观察到几种微小RNA的表达水平发生了改变。为了综述微小RNA是否可能成为人类胶质瘤有前景的生物标志物，我们全面检索了1966年至2010年的Cochrane图书馆、Medline和EMbase，语言限制为英文。我们发现，需要进一步了解微小RNA在特定细胞事件中的功能；准确且经济高效的微小RNA检测技术的不断进步为微小RNA作为胶质瘤新型诊断生物标志物发挥非常有前景的作用提供了可能。
