Department of Ophthalmology, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
Graduate Program in Cognitive Science, Yonsei University, Seoul, Korea.
PLoS One. 2019 Jul 18;14(7):e0219934. doi: 10.1371/journal.pone.0219934. eCollection 2019.
To classify the risk factors that contribute to the development versus progression of retinopathy of prematurity (ROP).
The medical records of premature infants born with a birth weight (BW) less than 1501 g or a gestational age (GA) of 32 weeks or less were retrospectively reviewed. Twenty potential risk factors that may influence the development or progression of ROP were analyzed by univariate and multivariate logistic regression analyses. The progression of ROP was defined as type 1 ROP, threshold ROP, or aggressive posterior ROP for which treatment was recommended.
A total of 324 eyes were included; 157 eyes (48.5%) showed ROP development, and 48 eyes exhibited ROP progression (14.8% of all eyes and 30.6% of the ROP-developed eyes). According to the univariate and multivariate logistic regression analyses, prenatal steroid use, GA, the duration of mechanical ventilation, and respiratory distress syndrome were associated with the development of ROP. However, GA, bronchopulmonary dysplasia, the number of red blood cell units transfused, intraventricular hemorrhage, and periventricular leukomalacia were significantly correlated with ROP progression.
The risk factors that influenced ROP development versus ROP progression were not identical. Evaluating these risk factors during screening of high-risk premature infants will help determine the appropriate timing of examinations and treatment.
对导致早产儿视网膜病变（ROP）发生和进展的危险因素进行分类。
回顾性分析出生体重（BW）<1501g 或胎龄（GA）<32 周的早产儿的病历。通过单变量和多变量逻辑回归分析，对 20 种可能影响 ROP 发生和进展的潜在危险因素进行了分析。ROP 的进展定义为建议治疗的 1 型 ROP、阈值 ROP 或侵袭性后部 ROP。
共纳入 324 只眼；157 只眼（48.5%）出现 ROP 发生，48 只眼出现 ROP 进展（所有眼的 14.8%和 ROP 发生眼的 30.6%）。根据单变量和多变量逻辑回归分析，产前使用类固醇、GA、机械通气持续时间和呼吸窘迫综合征与 ROP 的发生有关。然而，GA、支气管肺发育不良、输血量、脑室内出血和脑室周围白质软化与 ROP 进展显著相关。
影响 ROP 发生和进展的危险因素并不相同。在对高危早产儿进行筛查时评估这些危险因素，有助于确定检查和治疗的适当时机。
