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人乳寡糖的化学合成：乳-N-新四糖（Galβ1→4GlcNAcβ1→3Galβ1→4Glc）。

The chemical synthesis of human milk oligosaccharides: Lacto-N-neotetraose (Galβ1→4GlcNAcβ1→3Galβ1→4Glc).

机构信息

Department of Chemistry and Biochemistry, University of Missouri - St. Louis, One University Boulevard, St. Louis, Missouri, 63121, USA.

Department of Chemistry and Biochemistry, University of Missouri - St. Louis, One University Boulevard, St. Louis, Missouri, 63121, USA.

出版信息

Carbohydr Res. 2019 Sep 1;483:107743. doi: 10.1016/j.carres.2019.107743. Epub 2019 Jul 11.

DOI:10.1016/j.carres.2019.107743
PMID:31319351
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6717531/
Abstract

The discovery of innovative methods that offer new capabilities for obtaining individual oligosaccharides from human milk will help to improve understanding their roles and boost practical applications. The total chemical synthesis of lacto-N-neotetraose (LNnT) has been completed using both linear and convergent strategies. The donor and acceptor protecting and leaving group combinations were found to be of paramount significance to successful couplings.

摘要

发现创新方法，为从人乳中获得个别低聚糖提供新的可能性，有助于提高对其作用的认识并推动实际应用。采用线性和汇聚策略，已完成乳-N-新四糖 (LNnT) 的全化学合成。发现供体和受体的保护和离去基团组合对成功偶联至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e07d/6717531/586f26c3ad8c/nihms-1535294-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e07d/6717531/3ed91e5a1778/nihms-1535294-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e07d/6717531/fba7878e64a7/nihms-1535294-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e07d/6717531/586f26c3ad8c/nihms-1535294-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e07d/6717531/3ed91e5a1778/nihms-1535294-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e07d/6717531/fba7878e64a7/nihms-1535294-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e07d/6717531/586f26c3ad8c/nihms-1535294-f0004.jpg

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