State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, Jiangsu, People's Republic of China.
Arch Microbiol. 2024 Aug 14;206(9):378. doi: 10.1007/s00203-024-04104-2.
Human milk oligosaccharides (HMOs) have been recognized as gold standard for infant development. 3-Fucosyllactose (3-FL), being one of the Generally Recognized as Safe HMOs, represents a core trisaccharide within the realm of HMOs; however, it has received comparatively less attention in contrast to extensively studied 2'-fucosyllactose. The objective of this review is to comprehensively summarize the health effects of 3-FL, including its impact on gut microbiota proliferation, antimicrobial effects, immune regulation, antiviral protection, and brain maturation. Additionally, the discussion also covers the commercial application and regulatory approval status of 3-FL. Lastly, an organized presentation of large-scale production methods for 3-FL aims to provide a comprehensive guide that highlights current strategies and challenges in optimization.
人乳寡糖（HMOs）已被公认为婴儿发育的黄金标准。3-岩藻糖基乳糖（3-FL）作为一种被广泛认为安全的 HMO 之一，是 HMO 领域内核心的三糖；然而，与广泛研究的 2'-岩藻糖基乳糖相比，它受到的关注相对较少。本综述的目的是全面总结 3-FL 的健康效应，包括其对肠道微生物群增殖、抗菌作用、免疫调节、抗病毒保护和大脑成熟的影响。此外，讨论还涵盖了 3-FL 的商业应用和监管批准状况。最后，对 3-FL 的大规模生产方法进行了有组织的介绍，旨在提供一个全面的指南，突出了当前优化策略和挑战。
