Department of Chemistry and Biochemistry, University of Missouri - St. Louis, One University Boulevard, St Louis, Missouri 63121, USA.
Org Biomol Chem. 2020 Mar 4;18(9):1747-1753. doi: 10.1039/d0ob00172d.
The first chemical synthesis of lacto-N-neohexaose (LNnH) has been completed using a convergent synthetic strategy. The reaction conditions and donor-acceptor combinations have been carefully refined to minimize side reactions and achieve high yields in all glycosylation steps. Lacto-N-neotetraose, another common human milk oligosaccharide, was also synthesized en route to the target LNnH.
首次采用汇聚式合成策略完成了乳-N-新四糖（LNnH）的化学全合成。仔细优化了反应条件和供体-受体组合，以最大限度地减少副反应，并在所有糖基化步骤中实现高产率。在合成目标 LNnH 的过程中，还合成了另一种常见的人乳寡糖——乳-N-四糖。
