J Phys Act Health. 2019 Aug 1;16(8):601-607. doi: 10.1123/jpah.2018-0256.
Physical activity is prescribed as a component of primary management for polycystic ovary syndrome (PCOS). This nonrandomized, therapeutic, open, single-arm study investigated the effects of progressive resistance training (PRT) on obesity indices in women with PCOS, and the relationship between obesity indices and telomere content.
A total of 45 women with PCOS and 52 with non-PCOS (controls), aged 18 to 37 years, with body mass indexes of 18 to 39.9 kg/m2, performed three 1-hour sessions of PRT per week, for 16 weeks. Before and after PRT, measures included anthropometric indices and regions of interest of fat mass distribution, quantified by dual-energy X-ray absorptiometry, metabolic and hormonal parameters, and telomere content. The general linear mixed models were used to determine the effects of PRT.
PRT did reduce the waist-to-height ratio, waist circumference, and the index of conicity among PCOS (P < .01). However, PRT did not influence regions of interest, body mass index, and WHR. After PRT, the telomere content was associated with regions of interest and anthropometric indices in whole group independent of PCOS (P < .05).
Resistance exercise improves obesity indices in PCOS, independent of changes in body weight, and the relationship between telomeres and obesity parameters in PCOS remain to be fully clarified.
身体活动被规定为多囊卵巢综合征（PCOS）主要管理的组成部分。这项非随机、治疗性、开放性、单臂研究调查了渐进式抗阻训练（PRT）对 PCOS 女性肥胖指数的影响，以及肥胖指数与端粒含量的关系。
共有 45 名 PCOS 女性和 52 名非 PCOS（对照组）女性，年龄 18 至 37 岁，体重指数为 18 至 39.9kg/m2，每周进行 3 次 1 小时的 PRT，共 16 周。在 PRT 前后，测量指标包括人体测量指数和通过双能 X 射线吸收法定量的脂肪质量分布的感兴趣区域、代谢和激素参数以及端粒含量。使用一般线性混合模型来确定 PRT 的效果。
PRT 确实降低了 PCOS 的腰高比、腰围和锥度指数（P<.01）。然而，PRT 并没有影响感兴趣区域、体重指数和 WHR。PRT 后，端粒含量与整个组的感兴趣区域和人体测量指数相关，与 PCOS 无关（P<.05）。
阻力运动改善了 PCOS 的肥胖指数，与体重变化无关，PCOS 中端粒与肥胖参数之间的关系仍有待充分阐明。
