血清 IGF-1 和维生素 D 水平降低与 2 型糖尿病患者的认知障碍有关。
Decreased Levels of Serum IGF-1 and Vitamin D Are Associated With Cognitive Impairment in Patients With Type 2 Diabetes.
机构信息
Department of Endocrinology, Shanghai General Hospital of Nanjing Medical University, Nanjing, China.
Department of Endocrinology, Shanghai Pudong New Area People's Hospital, Shanghai, China.
出版信息
Am J Alzheimers Dis Other Demen. 2019 Nov-Dec;34(7-8):450-456. doi: 10.1177/1533317519860334. Epub 2019 Jul 18.
Abstract
PURPOSE
To determine the association of serum insulin-like growth factor 1 (IGF-1) and vitamin D levels with cognition status in patients with type 2 diabetes mellitus (T2DM).
METHODS
A total of 173 patients with T2DM were recruited and divided into mild cognitive impairment (MCI) group (n = 94) and normal cognition (NC) group (n = 79). Levels of IGF-1 and 25(OH)D were measured and compared, and the correlations among IGF-1, 25(OH)D, and cognitive function were analyzed.
RESULTS
Insulin-like growth factor 1 and 25(OH)D levels significantly decreased in MCI group than those in the NC group (both < .001). Multiple stepwise regression analysis revealed that IGF-1 (β = .146, < .001) and 25(OH)D (β = .199, < .001) independently predicted Montreal Cognitive Assessment (MoCA) scores. Partial least square regression showed that contributions of both 25(OH)D ( < .001) and IGF-1 ( < .001) to MoCA scores were significant, while no cross-effect was observed between them ( = .714).
CONCLUSIONS
Low serum IGF-1 and 25(OH)D levels may separately predict poor cognitive performance in patients with diabetes.
摘要
目的
探讨 2 型糖尿病（T2DM）患者血清胰岛素样生长因子 1（IGF-1）和维生素 D 水平与认知状态的关系。
方法
选取 173 例 T2DM 患者，分为轻度认知障碍（MCI）组（n=94）和正常认知（NC）组（n=79）。检测 IGF-1 和 25（OH）D 水平并进行比较，分析 IGF-1、25（OH）D 与认知功能的相关性。
结果
MCI 组 IGF-1 和 25（OH）D 水平均明显低于 NC 组（均 <.001）。多元逐步回归分析显示，IGF-1（β=.146， <.001）和 25（OH）D（β=.199， <.001）独立预测蒙特利尔认知评估（MoCA）评分。偏最小二乘回归显示，25（OH）D（ <.001）和 IGF-1（ <.001）对 MoCA 评分的贡献均有统计学意义，两者之间无交叉效应（ =.714）。
结论
血清 IGF-1 和 25（OH）D 水平降低可能分别预测糖尿病患者认知功能不良。
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